| Literature DB >> 28737400 |
Kinthada Ramakumar1,2, Tapan Maji1,2, James J Partridge1,2, Jon A Tunge1,2.
Abstract
A new method is developed for the synthesis of spirooxindoles from amines and isatins via C-H functionalization. The reaction leverages the tert-amino effect to form an enolate-iminium intermediate via [1,5]-hydride shift followed by cyclization. Interestingly the hydride migrates to the N atom of a C═N, which is atypical for hydride additions to imines.Entities:
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Year: 2017 PMID： 28737400 DOI： 10.1021/acs.orglett.7b01752
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005