Susanne Roehr1, Tobias Luck1, Alexander Pabst1, Horst Bickel2, Hans-Helmut König3, Dagmar Lühmann4, Angela Fuchs5, Steffen Wolfsgruber6, Birgitt Wiese7, Siegfried Weyerer8, Edelgard Mösch2, Christian Brettschneider3, Tina Mallon4, Michael Pentzek5, Michael Wagner6, Silke Mamone7, Jochen Werle8, Martin Scherer4, Wolfgang Maier6, Frank Jessen9, Steffi G Riedel-Heller1. 1. Institute of Social Medicine,Occupational Health and Public Health (ISAP),University of Leipzig,Leipzig,Germany. 2. Department of Psychiatry,Klinikum rechts der Isar,Technical University of Munich,Munich,Germany. 3. Department of Health Economics and Health Services Research,Hamburg Center for Health Economics,University Medical Center Hamburg-Eppendorf,Hamburg,Germany. 4. Department of Primary Medical Care,Center for Psychosocial Medicine,University Medical Center Hamburg-Eppendorf,Hamburg,Germany. 5. Institute of General Practice,Medical Faculty,Heinrich-Heine-University Düsseldorf,Düsseldorf,Germany. 6. Department of Psychiatry,University of Bonn,Bonn,Germany. 7. Work Group Medical Statistics and IT-Infrastructure,Institute for General Practice,Hannover Medical School,Hannover,Germany. 8. Central Institute of Mental Health,Medical Faculty,Mannheim/Heidelberg University,Mannheim,Germany. 9. German Center for Neurodegenerative Diseases,DZNE,Bonn,Germany.
Abstract
BACKGROUND: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment. METHODS: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS). RESULTS: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001). CONCLUSION: SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.
BACKGROUND: Subjective cognitive decline (SCD), the potentially earliest notable manifestation of preclinical Alzheimer's disease and other dementias, was consistently associated with lower quality of life in cross-sectional studies. The aim of this study was to investigate whether such an association persists longitudinally - particularly with health-related quality of life (HRQoL) in older individuals without cognitive impairment. METHODS: Data were derived from follow-up 2-6 of the prospective Germany Study on Ageing, Cognition and Dementia in Primary Care (AgeCoDe) covering a total six-year observation period. We used linear mixed effects models to estimate the effect of SCD on HRQoL measured by the EQ-5D visual analogue scale (EQ VAS). RESULTS: Of 1,387 cognitively unimpaired individuals aged 82.2 years (SD = 3.2) on average, 702 (50.6%) reported SCD and 230 (16.6%) with SCD-related concerns. Effect estimates of the linear mixed effects models revealed lower HRQoL in individuals with SCD (unadjusted: -3.7 points on the EQ VAS, 95%CI = -5.3 to -2.1; SE = 0.8; p < 0.001; adjusted: -2.9 points, 95%CI = -3.9 to -1.9; SE = 0.5; p < 0.001) than in individuals without SCD. The effect was most pronounced in SCD with related concerns (unadjusted: -5.4, 95%CI = -7.6 to -3.2; SE = 1.1; p < 0.001; adjusted: -4.3, 95%CI = -5.8 to -2.9, SE = 0.7; p < 0.001). CONCLUSION:SCD constitutes a serious issue to older cognitively unimpaired individuals that is depicted in persisting lower levels of HRQoL beyond depressive symptoms and functional impairment. Therefore, SCD should be taken seriously in clinical practice.
Authors: Erin D Bouldin; Christopher A Taylor; Kenneth A Knapp; Christina E Miyawaki; Nicholas R Mercado; Karen G Wooten; Lisa C McGuire Journal: Int Psychogeriatr Date: 2020-09-04 Impact factor: 7.191
Authors: Leonie C P Banning; Eveline P C J Janssen; Renske E G Hamel; Marjolein de Vugt; Sebastian Köhler; Claire A G Wolfs; Saskia M Oosterveld; Rene J F Melis; Marcel G M Olde Rikkert; Roy P C Kessels; Yolande A L Pijnenburg; Ted Koene; Wiesje M van der Flier; Philip Scheltens; Pieter Jelle Visser; Frans R J Verhey; Pauline Aalten; Inez H G B Ramakers Journal: J Geriatr Psychiatry Neurol Date: 2019-10-23 Impact factor: 2.680
Authors: Zulzikry Hafiz Abu Bakar; Hanafi Ahmad Damanhuri; Suzana Makpol; Wan Mohd Aizat Wan Kamaruddin; Nur Fathiah Abdul Sani; Ahmad Imran Zaydi Amir Hamzah; Khairun Nain Nor Aripin; Mohd Dzulkhairi Mohd Rani; Nor Azila Noh; Rosdinom Razali; Musalmah Mazlan; Hamzaini Abdul Hamid; Mazlyfarina Mohamad; Wan Zurinah Wan Ngah Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472