Karen M Vuckovic1, Houry Puzantian1. 1. Department of Biobehavioral Health Science, University of Illinois at Chicago College of Nursing, Chicago, IL, USA.
Abstract
BACKGROUND/AIMS: The 6-minute walk test is a measure of functional capacity in patients with heart failure (HF) or chronic kidney disease (CKD). The association between estimated glomerular filtration rate (eGFR) and 6-minute walk distance (6MWD) has not been investigated in African-Americans (AA), despite them having a higher incidence of CKD and chronic HF. Thus, our aim was to determine if eGFR was an independent predictor of 6MWD in AA >50 years of age with HF. METHODS: In this cross-sectional study, we examined the relationship between eGFR and 6MWD in 45 AA patients with HF from an urban outpatient HF clinic, using logistic regression with bootstrapping. RESULTS: The sample consisted of 53% females; mean age = 64.8 ± 9 years, mean eGFR = 61.6 ± 20 mL/min/1.73 m2, and mean 6MWD = 222 ± 78 m. A decrease in eGFR by 10 mL/min/1.73 m2 was associated with 46% higher odds (p = 0.02) of a 6MWD ≤200 m in an unadjusted model and 39-41% higher odds (p = 0.03) of a 6MWD ≤200 m in adjusted models. CONCLUSION: A decrease in eGFR significantly predicted a shorter 6MWD in AA patients with HF. Therefore, a reduction in eGFR may be used as an early marker to identify and manage declining functional capacity in these patients.
BACKGROUND/AIMS: The 6-minute walk test is a measure of functional capacity in patients with heart failure (HF) or chronic kidney disease (CKD). The association between estimated glomerular filtration rate (eGFR) and 6-minute walk distance (6MWD) has not been investigated in African-Americans (AA), despite them having a higher incidence of CKD and chronic HF. Thus, our aim was to determine if eGFR was an independent predictor of 6MWD in AA >50 years of age with HF. METHODS: In this cross-sectional study, we examined the relationship between eGFR and 6MWD in 45 AA patients with HF from an urban outpatient HF clinic, using logistic regression with bootstrapping. RESULTS: The sample consisted of 53% females; mean age = 64.8 ± 9 years, mean eGFR = 61.6 ± 20 mL/min/1.73 m2, and mean 6MWD = 222 ± 78 m. A decrease in eGFR by 10 mL/min/1.73 m2 was associated with 46% higher odds (p = 0.02) of a 6MWD ≤200 m in an unadjusted model and 39-41% higher odds (p = 0.03) of a 6MWD ≤200 m in adjusted models. CONCLUSION: A decrease in eGFR significantly predicted a shorter 6MWD in AA patients with HF. Therefore, a reduction in eGFR may be used as an early marker to identify and manage declining functional capacity in these patients.
Entities:
Keywords:
Functional capacity; Heart failure; Kidney disease; Six-minute walk test
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