Jenni Leppanen1, Valentina Cardi2, Yannis Paloyelis3, Andy Simmons3, Kate Tchanturia4, Janet Treasure2. 1. King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, United Kingdom. Electronic address: jenni.leppanen@kcl.ac.uk. 2. King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, United Kingdom. 3. King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Neuroimaging, Division of Neuroscience, United Kingdom. 4. King's College London, The Institute of Psychiatry, Psychology, and Neuroscience, Department of Psychological Medicine, United Kingdom; Illia State University, Department of Psychology, Tbilisi, Georgia.
Abstract
BACKGROUND: People with anorexia nervosa (AN) have difficulties in a wide range of social-emotional processes. Previous work suggests atypical involvement of the prefrontal cortex (PFC), amygdala, insula, and fusiform gyri during social-emotional processing in AN. METHODS: Twenty women with AN and twenty healthy comparison (HC) women were presented with happy, fearful, and neutral faces during a functional magnetic resonance imaging study. Group differences were investigated in the following regions of interest: lateral PFC, amygdala, insula, and fusiform gyri. RESULTS: The HC participants showed significantly increased recruitment of the ventrolateral PFC and amygdala in the fearful > neutral contrast relative to the AN participants. The AN participants showed a significantly increased recruitment of a small cluster in the right posterior insula in the happy > neutral contrast. CONCLUSIONS: These findings are in line with the hypothesis that people with AN have a blunted response to negative and atypical exaggerated response to positive emotionally provoking stimuli.
BACKGROUND:People with anorexia nervosa (AN) have difficulties in a wide range of social-emotional processes. Previous work suggests atypical involvement of the prefrontal cortex (PFC), amygdala, insula, and fusiform gyri during social-emotional processing in AN. METHODS: Twenty women with AN and twenty healthy comparison (HC) women were presented with happy, fearful, and neutral faces during a functional magnetic resonance imaging study. Group differences were investigated in the following regions of interest: lateral PFC, amygdala, insula, and fusiform gyri. RESULTS: The HC participants showed significantly increased recruitment of the ventrolateral PFC and amygdala in the fearful > neutral contrast relative to the AN participants. The AN participants showed a significantly increased recruitment of a small cluster in the right posterior insula in the happy > neutral contrast. CONCLUSIONS: These findings are in line with the hypothesis that people with AN have a blunted response to negative and atypical exaggerated response to positive emotionally provoking stimuli.
Authors: Maria Seidel; Joseph A King; Franziska Ritschel; Ilka Boehm; Daniel Geisler; Fabio Bernardoni; Matthias Beck; Sophie Pauligk; Ronald Biemann; Alexander Strobel; Thomas Goschke; Henrik Walter; Veit Roessner; Stefan Ehrlich Journal: Neuroimage Clin Date: 2017-12-24 Impact factor: 4.881
Authors: D Rangaprakash; Cara Bohon; Katherine E Lawrence; Teena Moody; Francesca Morfini; Sahib S Khalsa; Michael Strober; Jamie D Feusner Journal: Front Psychiatry Date: 2018-06-26 Impact factor: 4.157