Maria Didriksen1, Andreas S Rigas1, Richard P Allen2, Brendan J Burchell3, Emanuele Di Angelantonio4, Maria H Nielsen1, Poul Jennum5, Thomas Werge6, Christian Erikstrup7, Ole B Pedersen8, Mie T Bruun9, Kristoffer S Burgdorf1, Erik Sørensen1, Henrik Ullum10. 1. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 2. Department of Neurology, John Hopkins University School of Medicine, Baltimore, MD, USA. 3. Faculty of Social and Political Sciences, University of Cambridge, Cambridge, UK. 4. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Institute for Health Research, University of Cambridge, Blood and Transplant Research Unit in Donor Health and Genomics Cambridge, UK. 5. Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup, Denmark; Faculty of Health, University of Copenhagen, Copenhagen, Denmark. 6. Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; IPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark. 7. Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. 8. Department of Clinical Immunology, Nastved Sygehus, Nastved, Denmark. 9. Department of Clinical Immunology, Odense University Hospital, Odense, Denmark. 10. Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: henrik.ullum@regionh.dk.
Abstract
OBJECTIVE: Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by uncomfortable sensations in the legs. RLS often occurs as a comorbid condition. Besides an increased risk of iron deficiency, blood donors are considered to be generally healthy. Blood donors are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency. The objective of this study is therefore to estimate the RLS prevalence and identify associated biological, sociodemographic, economic, and lifestyle factors in a population of blood donors. METHODS: A total of 13,448 blood donors enrolled in the Danish Blood Donor Study from May 2015 to May 2016. RLS cases were identified using the validated Cambridge-Hopkins RLS-questionnaire. Logistic regression models were applied to assess the relationship between RLS and data on socially related factors collected using questionnaires and population registers. RESULTS: In this study, 7.2% women and 4.5% men were classified with RLS. RLS was associated with: female sex, high age, smoking, frequent alcohol consumption, and low education. RLS-related symptoms were associated with obesity, parity and donation intensity three years prior to inclusion among women. RLS was not related to: reduced plasma ferritin, employment status, and income. CONCLUSIONS: RLS is a frequent disorder in otherwise healthy individuals. The associations discovered in this study can be utilized in preventing or reducing RLS symptoms.
OBJECTIVE:Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by uncomfortable sensations in the legs. RLS often occurs as a comorbid condition. Besides an increased risk of iron deficiency, blood donors are considered to be generally healthy. Blood donors are therefore an ideal population for studying factors associated with RLS occurrence, herein the role of iron. It is suggested that RLS is linked to sex, age, low socioeconomic status, unhealthy lifestyle, and iron deficiency. The objective of this study is therefore to estimate the RLS prevalence and identify associated biological, sociodemographic, economic, and lifestyle factors in a population of blood donors. METHODS: A total of 13,448 blood donors enrolled in the Danish Blood Donor Study from May 2015 to May 2016. RLS cases were identified using the validated Cambridge-Hopkins RLS-questionnaire. Logistic regression models were applied to assess the relationship between RLS and data on socially related factors collected using questionnaires and population registers. RESULTS: In this study, 7.2% women and 4.5% men were classified with RLS. RLS was associated with: female sex, high age, smoking, frequent alcohol consumption, and low education. RLS-related symptoms were associated with obesity, parity and donation intensity three years prior to inclusion among women. RLS was not related to: reduced plasma ferritin, employment status, and income. CONCLUSIONS:RLS is a frequent disorder in otherwise healthy individuals. The associations discovered in this study can be utilized in preventing or reducing RLS symptoms.
Authors: Brienne Miner; Thomas M Gill; H Klar Yaggi; Nancy S Redeker; Peter H Van Ness; Ling Han; Carlos A Vaz Fragoso Journal: J Am Geriatr Soc Date: 2018-05-21 Impact factor: 5.562
Authors: Maria Didriksen; Muhammad Sulaman Nawaz; Joseph Dowsett; Steven Bell; Christian Erikstrup; Ole B Pedersen; Erik Sørensen; Poul J Jennum; Kristoffer S Burgdorf; Brendan Burchell; Adam S Butterworth; Nicole Soranzo; David B Rye; Lynn Marie Trotti; Prabhjyot Saini; Lilja Stefansdottir; Sigurdur H Magnusson; Gudmar Thorleifsson; Thordur Sigmundsson; Albert P Sigurdsson; Katja Van Den Hurk; Franke Quee; Michael W T Tanck; Willem H Ouwehand; David J Roberts; Eric J Earley; Michael P Busch; Alan E Mast; Grier P Page; John Danesh; Emanuele Di Angelantonio; Hreinn Stefansson; Henrik Ullum; Kari Stefansson Journal: Commun Biol Date: 2020-11-25
Authors: Eric J Earley; Maria Didriksen; Bryan R Spencer; Joseph E Kiss; Christian Erikstrup; Ole B Pedersen; Erik Sørensen; Kristoffer S Burgdorf; Steven H Kleinman; Alan E Mast; Michael P Busch; Henrik Ullum; Grier P Page Journal: Sleep Date: 2021-04-09 Impact factor: 5.849