Jeng-Dau Tsai1,2, Hsuan-Ju Chen3,4, Min-Sho Ku1,2, Shan-Ming Chen1,2, Chih-Chuan Hsu5, Min-Che Tung6, Che-Chen Lin7, Hsing-Yi Chang8, Ji-Nan Sheu9,10. 1. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan. 2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. 4. College of Medicine, China Medical University, Taichung, Taiwan. 5. Department of Pediatrics, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan. 6. Department of Surgery, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan. 7. Healthcare Service Research Center, Taichung Veterans General Hospital, Taichung, Taiwan. 8. Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan. 9. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan. cshy098@csh.org.tw. 10. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. cshy098@csh.org.tw.
Abstract
BACKGROUND: Little is known about the associations between allergic disease, sleep-disordered breathing (SDB), and childhood nocturnal enuresis (NE). We examined whether allergic disease and SDB were associated with childhood NE. METHODS: Data were assessed from the 2007-2012 Taiwan National Health Insurance Research Database. We enrolled 4308 children aged 5-18 years having NE diagnosis and age- and sex-matched 4308 children as the control group. The odds ratios of NE were calculated to determine an association with preexisting allergic disease and SDB. RESULTS: A total of 8616 children were included in the analysis. Prevalence of allergic diseases and SDB was significantly higher for the NE group than the control group (all p < 0.001). After adjusting odds ratios for potential confounding factors, except asthma, children with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and obstructive sleep apnea (OSA) had significantly higher odds of NE compared with children never diagnosed. With stratification for sex, girls with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, OSA, and snoring had significantly higher odds of NE, compared with girls never diagnosed. Only boys with allergic rhinitis and OSA were associated with increased odds of NE. With stratification for age, children aged 5-12 years with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and OSA had significantly higher odds of NE compared with those never diagnosed. Odds of NE increased with the number of comorbid allergic diseases. CONCLUSIONS: Allergic diseases and SDB are associated with increased odds of childhood NE. The odds of NE increased with the number of comorbid allergic diseases present.
BACKGROUND: Little is known about the associations between allergic disease, sleep-disordered breathing (SDB), and childhood nocturnal enuresis (NE). We examined whether allergic disease and SDB were associated with childhood NE. METHODS: Data were assessed from the 2007-2012 Taiwan National Health Insurance Research Database. We enrolled 4308 children aged 5-18 years having NE diagnosis and age- and sex-matched 4308 children as the control group. The odds ratios of NE were calculated to determine an association with preexisting allergic disease and SDB. RESULTS: A total of 8616 children were included in the analysis. Prevalence of allergic diseases and SDB was significantly higher for the NE group than the control group (all p < 0.001). After adjusting odds ratios for potential confounding factors, except asthma, children with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and obstructive sleep apnea (OSA) had significantly higher odds of NE compared with children never diagnosed. With stratification for sex, girls with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, OSA, and snoring had significantly higher odds of NE, compared with girls never diagnosed. Only boys with allergic rhinitis and OSA were associated with increased odds of NE. With stratification for age, children aged 5-12 years with allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and OSA had significantly higher odds of NE compared with those never diagnosed. Odds of NE increased with the number of comorbid allergic diseases. CONCLUSIONS:Allergic diseases and SDB are associated with increased odds of childhood NE. The odds of NE increased with the number of comorbid allergic diseases present.
Authors: Joseph G Barone; Christopher Hanson; Daniel G DaJusta; Kevin Gioia; Sandra J England; Dona Schneider Journal: Pediatrics Date: 2009-07 Impact factor: 7.124
Authors: R Chimenz; S Manti; C Fede; G Stroscio; C Visalli; A Nicotera; G Di Rosa; A C Romeo; V Salpietro; C Cuppari Journal: J Biol Regul Homeost Agents Date: 2015 Apr-Jun Impact factor: 1.711
Authors: Pietro Ferrara; Roberta Autuori; Flavia Dosa; Alessandro Di Lucia; Antonio Gatto; Antonio Chiaretti Journal: Indian J Nephrol Date: 2019 Sep-Oct