| Literature DB >> 2873397 |
J D Clemens, D A Sack, J R Harris, J Chakraborty, M R Khan, B F Stanton, B A Kay, M U Khan, M Yunus, W Atkinson.
Abstract
The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p less than 0.0001), and 11 cases in the WC group (protective efficacy 58%; p less than 0.01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus greater than 10 years) and for different severities of cholera.Entities:
Keywords: Asia; Bangladesh; Biology; Delivery Of Health Care; Developing Countries; Diarrhea--prevention and control; Diseases; Double-blind Studies; Gastrointestinal Effects; Health; Health Services; Immunization; Medicine; Physiology; Preventive Medicine; Primary Health Care; Research Methodology; Southern Asia; Studies; Vaccination--administraction and dosage
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Year: 1986 PMID： 2873397 DOI： 10.1016/s0140-6736(86)91944-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321