| Literature DB >> 2873353 |
R D Oberhaensli, D Hilton-Jones, P J Bore, L J Hands, R P Rampling, G K Radda.
Abstract
The bioenergetic state of 15 human tumours was examined with phosphorus-31 magnetic resonance spectroscopy. A striking diversity in metabolic patterns was observed, and significant differences from normal tissue were seen in all cases. A common feature was an elevation of intracellular pH, which may be related to an increase in Na+/H+ exchange during cell activation. It is unlikely that the patterns observed directly correlate with malignancy, but characterisation of the energetic state of a given tumour in a given physiological environment may help in the design and evaluation of interventions for that specific case.Entities:
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Year: 1986 PMID： 2873353 DOI： 10.1016/s0140-6736(86)92558-4
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321