Literature DB >> 28732936

Oxygen and Indocyanine Green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells.

Rong Ma1, Qiang Wu2, Ting Si3, Shufang Chang4, Ronald X Xu5.   

Abstract

Oxygen and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT). The produced OI-MPs agent showed stable optical properties, superior imaging depth in near infrared (NIR) fluorescence imaging, and enhanced acoustic contrast after ultrasound mediation. We hypothesized that encapsulating ICG and oxygen in microparticles would enhance reactive oxygen species (ROS) production in SDT. This hypothesis was validated in a cell-free environment. We further hypothesized that ultrasound mediated fragmentation of the OI-MPs would induce cytotoxicity and apoptosis of cancer cells. This hypothesis was validated in SKOV3 ovarian cancer cells. Our research demonstrated that OI-MPs can be potentially used as a dual-mode theranostic agent for image guided SDT with enhanced efficacy. Further study is needed to delineate the mechanism of ROS-induced cell apoptosis and optimize the OI-MPs formulation for the maximal anti-cancer potency.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Coaxial flow focusing; Indocyanine Green; Multifunctional microparticles; Oxygen; Sonodynamic therapy; Ultrasonic image

Mesh：

Substances：

Year:  2017        PMID： 28732936     DOI： 10.1016/j.ultsonch.2017.03.019

Source DB:  PubMed          Journal:  Ultrason Sonochem        ISSN： 1350-4177            Impact factor:   7.491


  7 in total

1.  Bifunctional Therapeutic Application of Low-Frequency Ultrasound Associated with Zinc Phthalocyanine-Loaded Micelles.

Authors:  Yugo A Martins; Maria J V Fonseca; Theo Z Pavan; Renata F V Lopez
Journal:  Int J Nanomedicine       Date:  2020-10-20

2.  A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells.

Authors:  Chunyan Chen; Jiangchuan Sun; Shuning Chen; Yujiao Liu; Shenyin Zhu; Zhigang Wang; Shufang Chang
Journal:  Int J Nanomedicine       Date:  2019-01-21

3.  Membrane-permeabilized sonodynamic therapy enhances drug delivery into macrophages.

Authors:  Zhengyu Cao; Tianyi Zhang; Xin Sun; Mingyu Liu; Zhaoqian Shen; Bicheng Li; Xuezhu Zhao; Hong Jin; Zhiguo Zhang; Ye Tian
Journal:  PLoS One       Date:  2019-06-10       Impact factor: 3.240

4.  Local Tumor Ischemia-Reperfusion Mediated By Ultrasound-Targeted Microbubble Destruction Enhances The Anti-Tumor Efficacy Of Doxorubicin Chemotherapy.

Authors:  Manxiang Wu; Zhuqing Song; Shiyu Zhang; Qing Dan; Caiyun Tang; Chao Peng; Yu Liang; Li Zhang; Hao Wang; Yingjia Li
Journal:  Cancer Manag Res       Date:  2019-11-05       Impact factor: 3.989

5.  Air-Filled Bubbles Stabilized by Gold Nanoparticle/Photodynamic Dye Hybrid Structures for Theranostics.

Authors:  Roman A Barmin; Polina G Rudakovskaya; Olga I Gusliakova; Olga A Sindeeva; Ekaterina S Prikhozhdenko; Elizaveta A Maksimova; Ekaterina N Obukhova; Vasiliy S Chernyshev; Boris N Khlebtsov; Alexander A Solovev; Gleb B Sukhorukov; Dmitry A Gorin
Journal:  Nanomaterials (Basel)       Date:  2021-02-06       Impact factor: 5.076

6.  RNA-Seq Explores the Mechanism of Oxygen-Boosted Sonodynamic Therapy Based on All-in-One Nanobubbles to Enhance Ferroptosis for the Treatment of HCC.

Authors:  Yichi Chen; Haitao Shang; Chunyue Wang; Jiaqi Zeng; Shentao Zhang; Bolin Wu; Wen Cheng
Journal:  Int J Nanomedicine       Date:  2022-01-07

7.  Dual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer.

Authors:  Shuning Chen; Yujiao Liu; Shenyin Zhu; Chunyan Chen; Wan Xie; Linlin Xiao; Yi Zhu; Lan Hao; Zhigang Wang; Jiangchuan Sun; Shufang Chang
Journal:  Drug Deliv       Date:  2018-11       Impact factor: 6.419
  7 in total

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