Literature DB >> 28732687

Selective Therapeutic Intervention: A Challenge against Off-Target Effects.

Filip Rázga1, Veronika Némethová2.   

Abstract

Despite the massive global spend on biology-driven drug discovery, tackling the issue of side effects and adverse events resulting from drug promiscuity represents a persistent challenge. Although delivering authentic medical innovations today is more complex than ever, minimization of off-target effects should be a priority.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords:  drug design; off-targets; selective intervention; side effects; target recognition

Mesh:

Year:  2017        PMID: 28732687     DOI: 10.1016/j.molmed.2017.06.007

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN: 1471-4914            Impact factor:   11.951


  4 in total

1.  A Middle-Out Modeling Strategy to Extend a Colon Cancer Logical Model Improves Drug Synergy Predictions in Epithelial-Derived Cancer Cell Lines.

Authors:  Eirini Tsirvouli; Vasundra Touré; Barbara Niederdorfer; Miguel Vázquez; Åsmund Flobak; Martin Kuiper
Journal:  Front Mol Biosci       Date:  2020-10-09

Review 2.  Lipoprotein-based drug delivery.

Authors:  Sara Busatto; Sierra A Walker; Whisper Grayson; Anthony Pham; Ming Tian; Nicole Nesto; Jacqueline Barklund; Joy Wolfram
Journal:  Adv Drug Deliv Rev       Date:  2020-08-11       Impact factor: 15.470

3.  Effective Reduction of SARS-CoV-2 RNA Levels Using a Tailor-Made Oligonucleotide-Based RNA Inhibitor.

Authors:  Veronika Nemethova; Petra Mazancova; Michal Selc; Kristina Jakic; Lucia Uhelska; Boglarka Nemethova; Alexandra Poturnayova; Lubos Drgona; Andrea Babelova; Filip Razga
Journal:  Viruses       Date:  2022-03-25       Impact factor: 5.048

4.  Chronic myelogenous leukemia on target.

Authors:  Veronika Némethová; Filip Rázga
Journal:  Cancer Med       Date:  2018-06-14       Impact factor: 4.452

  4 in total

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