Frej Stilling1, Sara Wallenius2, Karl Michaëlsson3, Christine Dalgård4, Kerstin Brismar5, Alicja Wolk6. 1. Unit of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Electronic address: frej.stilling@ki.se. 2. Unit of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Electronic address: sarawallenius@hotmail.com. 3. Department of Surgical Sciences, Section of Orthopedics, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden. Electronic address: karl.michaelsson@surgsci.uu.se. 4. Department of Public Health, Environmental Medicine, University of Southern Denmark, Winsløws Vej 17, Odense, Denmark. Electronic address: cdalgaard@health.sdu.dk. 5. Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden. Electronic address: Kerstin.Brismar@ki.se. 6. Unit of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Electronic address: alicja.wolk@ki.se.
Abstract
OBJECTIVE: Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass. DESIGN: Cross-sectional analysis of 4908 women, between 55 and 85years old, participating in the Swedish Mammography Cohort-Clinical. METHODS: We defined low relative muscle mass (LRMM) as an appendicular lean mass divided by height squared of less than 5.45 (kg/m2), assessed by dual energy x-ray absorptiometry. IGFBP-1 was measured by radioimmunoassay. Logistic regression was used to calculate odds-ratios of LRMM across quartiles of IGFBP-1. RESULTS: The odds of LRMM increased across quartiles of IGFBP-1. In the age-adjusted model the odds-ratio (OR) of LRMM was 3.41 (95% CI: 2.55-4.56), comparing the highest to the lowest quartile. This estimate was attenuated in multivariate models (OR: 1.84, 95% CI: 1.34-2.53), mainly due to inclusion of fat mass index. CONCLUSION: Women with higher IGFBP-1 were more likely to have a low relative muscle mass. High IGFBP-1 may be a marker of a catabolic state.
OBJECTIVE: Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass. DESIGN: Cross-sectional analysis of 4908 women, between 55 and 85years old, participating in the Swedish Mammography Cohort-Clinical. METHODS: We defined low relative muscle mass (LRMM) as an appendicular lean mass divided by height squared of less than 5.45 (kg/m2), assessed by dual energy x-ray absorptiometry. IGFBP-1 was measured by radioimmunoassay. Logistic regression was used to calculate odds-ratios of LRMM across quartiles of IGFBP-1. RESULTS: The odds of LRMM increased across quartiles of IGFBP-1. In the age-adjusted model the odds-ratio (OR) of LRMM was 3.41 (95% CI: 2.55-4.56), comparing the highest to the lowest quartile. This estimate was attenuated in multivariate models (OR: 1.84, 95% CI: 1.34-2.53), mainly due to inclusion of fat mass index. CONCLUSION:Women with higher IGFBP-1 were more likely to have a low relative muscle mass. High IGFBP-1 may be a marker of a catabolic state.
Authors: Kaleigh C Sims; Katey L Schwendinger; Dana B Szymkowicz; Jonathan R Swetenberg; Lisa J Bain Journal: J Toxicol Environ Health A Date: 2019-02-07
Authors: Siphiwe N Dlamini; Shane A Norris; Amy E Mendham; Asanda Mtintsilana; Kate A Ward; Tommy Olsson; Julia H Goedecke; Lisa K Micklesfield Journal: Sci Rep Date: 2022-06-09 Impact factor: 4.996