Literature DB >> 28732205

Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing.

Yuanliang Zhai1, Ningning Li2, Hanlun Jiang3, Xuhui Huang3, Ning Gao4, Bik Kwoon Tye5.   

Abstract

A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2-7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2-7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acrobat Model for pre-RC assembly; DNA replication initiation; Mcm2–7; ORC-Cdc6-Cdt1-MCM; cryo-EM structures

Mesh：

Substances：

Year:  2017        PMID： 28732205     DOI： 10.1016/j.molcel.2017.06.016

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  20 in total

1.  MCM6 Promotes Hepatocellular Carcinoma Progression via the Notch Pathway: Clinical, Functional, and Genomic Insights.

Authors:  Liangjuan Hou; Xin Zeng; Xuan Li; Chune Zhao; Juan Zou; Yukun Li; Gang Liu
Journal:  Comput Math Methods Med       Date:  2022-06-09       Impact factor: 2.809

2.  Exploring cisplatin resistance in ovarian cancer through integrated bioinformatics approach and overcoming chemoresistance with sanguinarine.

Authors:  Lihua Yang; Hongbo Zhao; Xueqin Yin; Hong Liang; Zhi Zheng; Qiang Shen; Wanqin Hu
Journal:  Am J Transl Res       Date:  2020-03-15       Impact factor: 4.060

3.  Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance.

Authors:  Zuanning Yuan; Huilin Li
Journal:  Biochem J       Date:  2020-09-30       Impact factor: 3.857

Review 4.  A structural view of the initiators for chromosome replication.

Authors:  Kin Fan On; Matt Jaremko; Bruce Stillman; Leemor Joshua-Tor
Journal:  Curr Opin Struct Biol       Date:  2018-09-12       Impact factor: 6.809

Review 5.  Regulation of chromatin structure and function: insights into the histone chaperone FACT.

Authors:  Peijun Wang; Wanting Yang; Shuxin Zhao; Buhe Nashun
Journal:  Cell Cycle       Date:  2021-02-16       Impact factor: 4.534

6.  Cryo-EM structure of a licensed DNA replication origin.

Authors:  Ferdos Abid Ali; Max E Douglas; Julia Locke; Valerie E Pye; Andrea Nans; John F X Diffley; Alessandro Costa
Journal:  Nat Commun       Date:  2017-12-21       Impact factor: 14.919

7.  Elevated expression of minichromosome maintenance 3 indicates poor outcomes and promotes G1/S cell cycle progression, proliferation, migration and invasion in colorectal cancer.

Authors:  He Zhou; Yongfu Xiong; Guangjun Zhang; Zuoliang Liu; Lifa Li; Songlin Hou; Tong Zhou
Journal:  Biosci Rep       Date:  2020-07-31       Impact factor: 3.840

8.  lncRNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5.

Authors:  Yingying Jiang; Haiyan Guo; Tong Tong; Fei Xie; Xing Qin; Xiaoning Wang; Wantao Chen; Jianjun Zhang
Journal:  Mol Ther       Date:  2021-06-08       Impact factor: 11.454

9.  Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

Authors:  Yasunori Noguchi; Zuanning Yuan; Lin Bai; Sarah Schneider; Gongpu Zhao; Bruce Stillman; Christian Speck; Huilin Li
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-25       Impact factor: 11.205

Review 10.  O-GlcNAc: A Sweetheart of the Cell Cycle and DNA Damage Response.

Authors:  Caifei Liu; Jing Li
Journal:  Front Endocrinol (Lausanne)       Date:  2018-07-30       Impact factor: 5.555
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