BACKGROUND & AIMS: Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. The aim of this study was the assessment of skin temperature, in relation to sleep-wake patterns, in patients with cirrhosis. METHODS: Fifty-three subjects were initially recruited, and 46 completed the study. Of the final 46, 12 were outpatients with cirrhosis, 13 inpatients with cirrhosis, 11 inpatients without cirrhosis and 10 healthy volunteers. All underwent baseline sleep-wake evaluation and blood sampling for inflammatory markers and morning melatonin levels. Distal/proximal skin temperature and their gradient (DPG) were recorded for 24 hours by a wireless device. Over this period subjects kept a sleep-wake diary. RESULTS: Inpatients with cirrhosis slept significantly less well than the other groups. Inpatients and outpatients with cirrhosis had higher proximal temperature and blunted rhythmicity compared to the other groups. Inpatients with/without cirrhosis had higher distal temperature values and blunted rhythmicity compared to the other groups. Inpatients and outpatients with cirrhosis had significantly lower DPG values compared to the other groups, and DPG reached near-zero values several hours later. Significant correlations were observed between temperature and sleep-wake variables and inflammatory markers. CONCLUSIONS: Alterations of distal/proximal skin temperature, their gradient and their time-course were observed in patients with cirrhosis, which may contribute to their sleep disturbances.
BACKGROUND & AIMS: Sleep preparation/onset are associated with peripheral vasodilatation and a decrease in body temperature. The hyperdynamic syndrome exhibited by patients with cirrhosis may impinge on sleep preparation, thus contributing to their difficulties falling asleep. The aim of this study was the assessment of skin temperature, in relation to sleep-wake patterns, in patients with cirrhosis. METHODS: Fifty-three subjects were initially recruited, and 46 completed the study. Of the final 46, 12 were outpatients with cirrhosis, 13 inpatients with cirrhosis, 11 inpatients without cirrhosis and 10 healthy volunteers. All underwent baseline sleep-wake evaluation and blood sampling for inflammatory markers and morning melatonin levels. Distal/proximal skin temperature and their gradient (DPG) were recorded for 24 hours by a wireless device. Over this period subjects kept a sleep-wake diary. RESULTS: Inpatients with cirrhosis slept significantly less well than the other groups. Inpatients and outpatients with cirrhosis had higher proximal temperature and blunted rhythmicity compared to the other groups. Inpatients with/without cirrhosis had higher distal temperature values and blunted rhythmicity compared to the other groups. Inpatients and outpatients with cirrhosis had significantly lower DPG values compared to the other groups, and DPG reached near-zero values several hours later. Significant correlations were observed between temperature and sleep-wake variables and inflammatory markers. CONCLUSIONS: Alterations of distal/proximal skin temperature, their gradient and their time-course were observed in patients with cirrhosis, which may contribute to their sleep disturbances.
Authors: Reem Satti; Noor-Ul-Hoda Abid; Matteo Bottaro; Michele De Rui; Maria Garrido; Mohammad R Raoufy; Sara Montagnese; Ali R Mani Journal: Front Physiol Date: 2019-02-19 Impact factor: 4.566
Authors: Tope Oyelade; Gabriele Canciani; Matteo Bottaro; Marta Zaccaria; Chiara Formentin; Kevin Moore; Sara Montagnese; Ali R Mani Journal: Front Physiol Date: 2020-12-09 Impact factor: 4.566
Authors: Céline Jouffe; Benjamin D Weger; Eva Martin; Florian Atger; Meltem Weger; Cédric Gobet; Divya Ramnath; Aline Charpagne; Delphine Morin-Rivron; Elizabeth E Powell; Matthew J Sweet; Mojgan Masoodi; N Henriette Uhlenhaut; Frédéric Gachon Journal: Proc Natl Acad Sci U S A Date: 2022-03-01 Impact factor: 12.779
Authors: Minjee Kim; Eric M Liotta; Matthew B Maas; Rosemary I Braun; Blas Garcia-Canga; Daniel R Ganger; Daniela P Ladner; Kathryn J Reid; Phyllis C Zee Journal: Sleep Date: 2021-06-11 Impact factor: 5.849