Rodolfo Mastropasqua1, Lisa Toto2, Alfonso Senatore3, Alessandro D'Uffizi3, Piergiorgio Neri4, Cesare Mariotti4, Marica Tina Maccarone5, Luca Di Antonio3. 1. Ophthalmology Clinic, Moorfields Eye Hospital, London, EC1V 2PD, UK. 2. Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, 66100, Chieti, Italy. l.toto@unich.it. 3. Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, 66100, Chieti, Italy. 4. Ophthalmology Clinic, University of Marche, Ancona, Italy. 5. Radiology Division, Santo-Spirito Hospital, Pescara, Italy.
Abstract
PURPOSE: To report clinical features of Susac's syndrome (SS) using optical coherence tomography angiography (OCTA). METHODS: Case report. RESULTS: A 25-year-old Caucasian female with a history of non-pulsatile migraine, tinnitus, and verbal apraxia complaining of peripheral scotoma in left eye due to branch retinal arteriole occlusion (BRAO) was diagnosed as having SS after audiometric test, brain magnetic resonance imaging, and multimodal retinal imaging. Fundus biomicroscopy and fluorescein angiography (FA) revealed the presence of retinal ischemia in the area of BRAO. The OCTA images showed decreased vascular perfusion of both superficial and deep plexuses in the area of the occluded arteriole with increase of vascular density values after treatment with intravenous glucocorticoids, cyclophosphamide, and aspirin. CONCLUSIONS: OCTA offers a valid alternative to the standard invasive FA, evaluating vascular perfusion in all capillary plexuses, and monitoring retinal microvascular flow changes during the course of BRAO, without dye injection.
PURPOSE: To report clinical features of Susac's syndrome (SS) using optical coherence tomography angiography (OCTA). METHODS: Case report. RESULTS: A 25-year-old Caucasian female with a history of non-pulsatile migraine, tinnitus, and verbal apraxia complaining of peripheral scotoma in left eye due to branch retinal arteriole occlusion (BRAO) was diagnosed as having SS after audiometric test, brain magnetic resonance imaging, and multimodal retinal imaging. Fundus biomicroscopy and fluorescein angiography (FA) revealed the presence of retinal ischemia in the area of BRAO. The OCTA images showed decreased vascular perfusion of both superficial and deep plexuses in the area of the occluded arteriole with increase of vascular density values after treatment with intravenous glucocorticoids, cyclophosphamide, and aspirin. CONCLUSIONS: OCTA offers a valid alternative to the standard invasive FA, evaluating vascular perfusion in all capillary plexuses, and monitoring retinal microvascular flow changes during the course of BRAO, without dye injection.
Authors: Marco A Bonini Filho; Mehreen Adhi; Talisa E de Carlo; Daniela Ferrara; Caroline R Baumal; Andre J Witkin; Elias Reichel; Laura Kuehlewein; SriniVas R Sadda; David Sarraf; Jay S Duker; Nadia K Waheed Journal: Retina Date: 2015-11 Impact factor: 4.256
Authors: Simone Alex Bagaglia; Franco Passani; Giovanni William Oliverio; Leandro Inferrera; Feliciana Menna; Alessandro Meduri; Cosimo Mazzotta Journal: Int J Environ Res Public Health Date: 2021-03-26 Impact factor: 3.390