Literature DB >> 28729360

Potential role of cyclophilin A in regulating cytokine secretion.

Farman Ullah Dawar1, Yang Xiong1, Muhammad Nasir Khan Khattak2,3, Jun Li4, Li Lin5,6, Jie Mei7.   

Abstract

Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation. This report reviews the literature related to the mechanism of CypA-dependent cytokine secretion and discusses this factor as a possible therapeutic target in inflammatory diseases. © Society for Leukocyte Biology.

Entities:  

Keywords:  CD147; diseases; inflammation; mechanism

Mesh：

Substances：

Year:  2017        PMID： 28729360     DOI： 10.1189/jlb.3RU0317-090RR

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  26 in total

1.  The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from Mosquito Cells in Association with the Intracellular Cholesterol Transporter Chaperone Caveolin Complex.

Authors:  Romel Rosales Ramirez; Juan E Ludert
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2.  Gracilin-Derivatives as Lead Compounds for Anti-inflammatory Effects.

Authors:  Sandra Gegunde; Amparo Alfonso; Eva Alonso; Rebeca Alvariño; Luis M Botana
Journal:  Cell Mol Neurobiol       Date:  2019-11-15       Impact factor: 5.046

3.  Inhibition of the cyclophilin A-CD147 interaction attenuates right ventricular injury and dysfunction after acute pulmonary embolism in rats.

Authors:  Guangdong Lu; Zhenyu Jia; Qingquan Zu; Jinxing Zhang; Linbo Zhao; Haibin Shi
Journal:  J Biol Chem       Date:  2018-06-18       Impact factor: 5.157

4.  Ciclosporin A in bilateral auto-immune chronic posterior uveitis associated with macular oedema: a Long-term Observational Safety and Efficacy Study.

Authors:  Munirah Alafaleq; Romain Freund; Marie-Aude Penet; Christine Fardeau; Corinne Isnard-Bagnis; Sophie Tezenas du Montcel; Gilbert Deray; Phuc LE Hoang; Bahram Bodaghi; Isabelle Tostivint
Journal:  Eye (Lond)       Date:  2021-10-30       Impact factor: 4.456

5.  Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman's Syndrome via HIF1α-Dependent Angiogenesis.

Authors:  Mira Park; Seok-Ho Hong; So Hee Park; Yeon Sun Kim; Seung Chel Yang; Hye-Ryun Kim; Songmi Noh; Sunghun Na; Hyung Keun Lee; Hyunjung J Lim; Sang Woo Lyu; Haengseok Song
Journal:  Mol Ther       Date:  2020-05-20       Impact factor: 11.454

Review 6.  Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation.

Authors:  Marco Cardone; Masahide Yano; Amy S Rosenberg; Montserrat Puig
Journal:  Front Immunol       Date:  2020-05-29       Impact factor: 7.561

7.  A staphylococcal cyclophilin carries a single domain and unfolds via the formation of an intermediate that preserves cyclosporin A binding activity.

Authors:  Soham Seal; Soumitra Polley; Subrata Sau
Journal:  PLoS One       Date:  2019-03-29       Impact factor: 3.240

8.  Cyclophilin Inhibitor NV556 Reduces Fibrosis and Hepatocellular Carcinoma Development in Mice With Non-Alcoholic Steatohepatitis.

Authors:  Joseph Kuo; Sonia Simón Serrano; Alvar Grönberg; Ramin Massoumi; Magnus Joakim Hansson; Philippe Gallay
Journal:  Front Pharmacol       Date:  2019-09-26       Impact factor: 5.810

9.  Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway.

Authors:  Tangying Li; Huibiao Quan; Huachuan Zhang; Leweihua Lin; Qianying Ou; Kaining Chen
Journal:  Bioengineered       Date:  2020-12       Impact factor: 3.269

Review 10.  A comprehensive review on drug repositioning against coronavirus disease 2019 (COVID19).

Authors:  Maryam Rameshrad; Majid Ghafoori; Amir Hooshang Mohammadpour; Mohammad Javad Dehghan Nayeri; Hossein Hosseinzadeh
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2020-05-19       Impact factor: 3.000
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