R Sauras1, A Keymer2, A Alonso-Solis1, A Díaz2, C Molins2, F Nuñez3, M Rabella2, A Roldán2, E Grasa4, E Alvarez1, M J Portella5, I Corripio1. 1. Psychiatric Department Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Carrer Sant Antoni M. Claret, 167, 08025 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carrer Dr. Aiguader, 88, 1(a) Planta, 08003 Barcelona, Spain. 2. Psychiatric Department Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Carrer Sant Antoni M. Claret, 167, 08025 Barcelona, Spain. 3. Neuroradiology Unit Hospital de Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Carrer Sant Antoni M. Claret, 167, 08025 Barcelona, Spain. 4. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carrer Dr. Aiguader, 88, 1(a) Planta, 08003 Barcelona, Spain. 5. Psychiatric Department Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona (UAB), Carrer Sant Antoni M. Claret, 167, 08025 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carrer Dr. Aiguader, 88, 1(a) Planta, 08003 Barcelona, Spain. Electronic address: mportella@santpau.cat.
Abstract
BACKGROUND: Abnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosis patients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder. METHODS: We studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls. MRI was performed at the time of the inclusion in the study. After one year, the whole sample was reevaluated and divided in two groups depending on the diagnoses (schizophrenia vs. non-schizophrenia). RESULTS: Patients who progressed to schizophrenia showed a significantly smaller left hippocampus volume than control group and no-schizophrenia group (F=3.54; df=2, 77; P=0.03). We also found significant differences in the morphology of the anterior hippocampus (CA1) of patients with first-episode psychosis who developed schizophrenia compared with patients who did not. CONCLUSIONS: These results are consistent with the assumption of hyperfunctioning dopaminergic cortico-subcortical circuits in schizophrenia, which might be related with an alteration of subcortical structures, such as the hippocampus, along the course of the disease. According with these results, hippocampus abnormalities may serve as a prognostic marker of clinical outcome in patients with a first-episode psychosis.
BACKGROUND: Abnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosispatients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder. METHODS: We studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls. MRI was performed at the time of the inclusion in the study. After one year, the whole sample was reevaluated and divided in two groups depending on the diagnoses (schizophrenia vs. non-schizophrenia). RESULTS:Patients who progressed to schizophrenia showed a significantly smaller left hippocampus volume than control group and no-schizophrenia group (F=3.54; df=2, 77; P=0.03). We also found significant differences in the morphology of the anterior hippocampus (CA1) of patients with first-episode psychosis who developed schizophrenia compared with patients who did not. CONCLUSIONS: These results are consistent with the assumption of hyperfunctioning dopaminergic cortico-subcortical circuits in schizophrenia, which might be related with an alteration of subcortical structures, such as the hippocampus, along the course of the disease. According with these results, hippocampus abnormalities may serve as a prognostic marker of clinical outcome in patients with a first-episode psychosis.
Authors: Suzanne N Avery; Maureen McHugo; Kristan Armstrong; Jennifer U Blackford; Neil D Woodward; Stephan Heckers Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2019-06-27
Authors: Soichiro Nakahara; Jessica A Turner; Vince D Calhoun; Kelvin O Lim; Bryon Mueller; Juan R Bustillo; Daniel S O'Leary; Sarah McEwen; James Voyvodic; Aysenil Belger; Daniel H Mathalon; Judith M Ford; Fabio Macciardi; Mitsuyuki Matsumoto; Steven G Potkin; Theo G M van Erp Journal: Psychol Med Date: 2019-06-03 Impact factor: 7.723
Authors: Jaana Suvisaari; Outi Mantere; Jaakko Keinänen; Teemu Mäntylä; Eva Rikandi; Maija Lindgren; Tuula Kieseppä; Tuukka T Raij Journal: Front Psychiatry Date: 2018-11-13 Impact factor: 4.157
Authors: Maureen McHugo; Kristan Armstrong; Maxwell J Roeske; Neil D Woodward; Jennifer U Blackford; Stephan Heckers Journal: Transl Psychiatry Date: 2020-09-01 Impact factor: 6.222