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Literature DB >> 28726006

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.

Yan Li^1,2, Juan Zhang², Yuying Lei³, Lechun Lyu^4,5, Ruiling Zuo¹, Ting Chen¹.

Abstract

Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker. However, there is a significant amount of work required to increase our current understanding of the role of microRNA-21 in skin fibrosis.

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28726006 DOI： 10.1007/s40291-017-0294-8

Source DB: PubMed Journal: Mol Diagn Ther ISSN： 1177-1062 Impact factor: 4.074

103 in total

1. The circulating cell-free microRNA profile in systemic sclerosis is distinct from both healthy controls and systemic lupus erythematosus.

Authors: Samantha O Steen; Line V Iversen; Anting Liu Carlsen; Mark Burton; Christoffer T Nielsen; Søren Jacobsen; Niels H H Heegaard
Journal: J Rheumatol Date: 2014-11-15 Impact factor: 4.666

Review 2. Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy.

Authors: Oliver Distler; Antonio Cozzio
Journal: Semin Immunopathol Date: 2015-11-17 Impact factor: 9.623

3. Clinical Outcome and Quality of Life After a Multimodal Therapy Approach to Ear Keloids.

Authors: Ute Walliczek; Stephan Engel; Christel Weiss; Christoph Aderhold; Christiane Lippert; Angela Wenzel; Karl Hörmann; Johannes David Schultz
Journal: JAMA Facial Plast Surg Date: 2015 Sep-Oct Impact factor: 4.611

Review 4. From genetics to epigenetics: new insights into keloid scarring.

Authors: Yongjing He; Zhenjun Deng; Mansour Alghamdi; Lechun Lu; Mark W Fear; Li He
Journal: Cell Prolif Date: 2017-01-05 Impact factor: 6.831

5. MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes.

Authors: Mohammed I Ahmed; Andrei N Mardaryev; Christopher J Lewis; Andrey A Sharov; Natalia V Botchkareva
Journal: J Cell Sci Date: 2011-10-07 Impact factor: 5.285

6. Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts.

Authors: Z-Y Wu; L Lu; J Liang; X-R Guo; P H Zhang; S-J Luo
Journal: Genet Mol Res Date: 2014-04-14

7. The role and mechanisms of action of SIRT6 in the suppression of postoperative epidural scar formation.

Authors: Xiaochen Fan; Junjie Chen; Da Shi; Jing Jia; Jia He; Liang Li; Tao Lei; Xuesong Chen
Journal: Int J Mol Med Date: 2016-03-11 Impact factor: 4.101

8. miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma.

Authors: Qin Zhu; Zhiming Wang; Yu Hu; Jindong Li; Xinying Li; Ledu Zhou; Yun Huang
Journal: Oncol Rep Date: 2012-02-09 Impact factor: 3.906

Review 9. MicroRNA: potential targets for the development of novel drugs?

Authors: Wei Wu
Journal: Drugs R D Date: 2010

10. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

Authors: Johan M Lorenzen; Celina Schauerte; Anika Hübner; Malte Kölling; Filippo Martino; Kristian Scherf; Sandor Batkai; Karina Zimmer; Ariana Foinquinos; Tamas Kaucsar; Jan Fiedler; Regalla Kumarswamy; Claudia Bang; Dorothee Hartmann; Shashi K Gupta; Jan Kielstein; Andreas Jungmann; Hugo A Katus; Frank Weidemann; Oliver J Müller; Hermann Haller; Thomas Thum
Journal: Eur Heart J Date: 2015-04-21 Impact factor: 29.983

15 in total

10. miR-21 modification enhances the performance of adipose tissue-derived mesenchymal stem cells for counteracting urethral stricture formation.

Authors: Zongcheng Feng; Hongrun Chen; Taozhu Fu; Lianfeng Zhang; Yushan Liu
Journal: J Cell Mol Med Date: 2018-09-04 Impact factor: 5.310

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment.

1. The circulating cell-free microRNA profile in systemic sclerosis is distinct from both healthy controls and systemic lupus erythematosus.

Review 2. Systemic sclerosis and localized scleroderma--current concepts and novel targets for therapy.

3. Clinical Outcome and Quality of Life After a Multimodal Therapy Approach to Ear Keloids.

Review 4. From genetics to epigenetics: new insights into keloid scarring.

5. MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes.

6. Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts.

7. The role and mechanisms of action of SIRT6 in the suppression of postoperative epidural scar formation.

8. miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma.

Review 9. MicroRNA: potential targets for the development of novel drugs?

10. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

1. MiR-3613-3p inhibits hypertrophic scar formation by down-regulating arginine and glutamate-rich 1.

Review 2. The Ubiquitin Proteasome System and Skin Fibrosis.

3. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation.

Review 4. Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid.

Review 5. MicroRNA-21: A Critical Pathogenic Factor of Diabetic Nephropathy.

6. MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts.

Review 7. Keloids: a review of therapeutic management.

Review 8. Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids.

Review 9. MicroRNA in localized scleroderma: a review of literature.

10. miR-21 modification enhances the performance of adipose tissue-derived mesenchymal stem cells for counteracting urethral stricture formation.