Shijun Li1, Xiaoying Li2. 1. Department of Geriatric Cardiology, Chinese PLA General Hospital at No. 28, Fuxing Road, Beijing, 100853, People's Republic of China. lishijun817@126.com. 2. Department of Geriatric Cardiology, Chinese PLA General Hospital at No. 28, Fuxing Road, Beijing, 100853, People's Republic of China.
Abstract
INTRODUCTION: Systolic blood pressure (SBP) is emerging as a predictor of outcome in chronic heart failure and low SBP has been shown to be related to higher mortality. AIM: To investigate the relationship between low SBP and long-term outcome in patients with heart failure with preserved ejection fraction (HFpEF). METHODS: We use prospectively collected data and recruited 297 patients with chronic HFpEF to investigate the relationship between low SBP at discharge and long-term outcome. SBP was recorded at discharge and analysed in a Cox regression model. The endpoint of interest was death from any cause. RESULTS: In follow-up period, the mortality rates were 61.4% for SBP <100 mmHg, and the survival rates decreased in SBP <100 mmHg as compared with the other SBP strata by using Kaplan-Meier analysis (χ 2 = 22.95, log rank P < 0.001). Compared to SBP 140-159 mmHg (reference category), the unadjusted hazard ratios for mortality were 3.29 (95% CI 1.45-7.47, P = 0.004) for SBP <100 mmHg. On multivariate analysis, adjustment for all variables, there still was an inverse relation between SBP and all cause mortality with a threshold at 100 mmHg (P = 0.002) and the adjusted hazard ratios were 3.16 (95% CI 1.15-8.68, P = 0.026) for SBP <100 mmHg. CONCLUSIONS: SBP at discharge is an independent predictor of long-term outcome and affects all-cause mortality, and SBP <100 mmHg at discharge is associated with excess long-term mortality in HFpEF.
INTRODUCTION: Systolic blood pressure (SBP) is emerging as a predictor of outcome in chronic heart failure and low SBP has been shown to be related to higher mortality. AIM: To investigate the relationship between low SBP and long-term outcome in patients with heart failure with preserved ejection fraction (HFpEF). METHODS: We use prospectively collected data and recruited 297 patients with chronic HFpEF to investigate the relationship between low SBP at discharge and long-term outcome. SBP was recorded at discharge and analysed in a Cox regression model. The endpoint of interest was death from any cause. RESULTS: In follow-up period, the mortality rates were 61.4% for SBP <100 mmHg, and the survival rates decreased in SBP <100 mmHg as compared with the other SBP strata by using Kaplan-Meier analysis (χ 2 = 22.95, log rank P < 0.001). Compared to SBP 140-159 mmHg (reference category), the unadjusted hazard ratios for mortality were 3.29 (95% CI 1.45-7.47, P = 0.004) for SBP <100 mmHg. On multivariate analysis, adjustment for all variables, there still was an inverse relation between SBP and all cause mortality with a threshold at 100 mmHg (P = 0.002) and the adjusted hazard ratios were 3.16 (95% CI 1.15-8.68, P = 0.026) for SBP <100 mmHg. CONCLUSIONS: SBP at discharge is an independent predictor of long-term outcome and affects all-cause mortality, and SBP <100 mmHg at discharge is associated with excess long-term mortality in HFpEF.
Authors: Inder S Anand; S William Tam; Thomas S Rector; Anne L Taylor; Michael L Sabolinski; W Tad Archambault; Kirkwood F Adams; Adeoye Y Olukotun; Manuel Worcel; Jay N Cohn Journal: J Am Coll Cardiol Date: 2006-12-14 Impact factor: 24.094
Authors: Clyde W Yancy; Mariell Jessup; Biykem Bozkurt; Javed Butler; Donald E Casey; Monica M Colvin; Mark H Drazner; Gerasimos S Filippatos; Gregg C Fonarow; Michael M Givertz; Steven M Hollenberg; JoAnn Lindenfeld; Frederick A Masoudi; Patrick E McBride; Pamela N Peterson; Lynne Warner Stevenson; Cheryl Westlake Journal: J Am Coll Cardiol Date: 2017-04-28 Impact factor: 24.094
Authors: Piotr Ponikowski; Adriaan A Voors; Stefan D Anker; Héctor Bueno; John G F Cleland; Andrew J S Coats; Volkmar Falk; José Ramón González-Juanatey; Veli-Pekka Harjola; Ewa A Jankowska; Mariell Jessup; Cecilia Linde; Petros Nihoyannopoulos; John T Parissis; Burkert Pieske; Jillian P Riley; Giuseppe M C Rosano; Luis M Ruilope; Frank Ruschitzka; Frans H Rutten; Peter van der Meer Journal: Eur J Heart Fail Date: 2016-05-20 Impact factor: 15.534
Authors: Linda B Piller; Sarah Baraniuk; Lara M Simpson; William C Cushman; Barry M Massie; Paula T Einhorn; Suzanne Oparil; Charles E Ford; James F Graumlich; Richard A Dart; David C Parish; Tamrat M Retta; Aloysius B Cuyjet; Syed Z Jafri; Curt D Furberg; Mohammad G Saklayen; Udho Thadani; Jeffrey L Probstfield; Barry R Davis Journal: Circulation Date: 2011-10-03 Impact factor: 29.690
Authors: R Sacha Bhatia; Jack V Tu; Douglas S Lee; Peter C Austin; Jiming Fang; Annick Haouzi; Yanyan Gong; Peter P Liu Journal: N Engl J Med Date: 2006-07-20 Impact factor: 91.245
Authors: Wilbert S Aronow; Jerome L Fleg; Carl J Pepine; Nancy T Artinian; George Bakris; Alan S Brown; Keith C Ferdinand; Mary Ann Forciea; William H Frishman; Cheryl Jaigobin; John B Kostis; Giuseppi Mancia; Suzanne Oparil; Eduardo Ortiz; Efrain Reisin; Michael W Rich; Douglas D Schocken; Michael A Weber; Deborah J Wesley Journal: J Am Coll Cardiol Date: 2011-04-26 Impact factor: 24.094