Literature DB >> 28724747

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain.

Bridgette D Semple1, Terence J O'Brien2, Kayleen Gimlin3, David K Wright4, Shi Eun Kim2, Pablo M Casillas-Espinosa2, Kyria M Webster2, Steven Petrou4, Linda J Noble-Haeusslein3,5.   

Abstract

Epilepsy after pediatric traumatic brain injury (TBI) is associated with poor quality of life. This study aimed to characterize post-traumatic epilepsy in a mouse model of pediatric brain injury, and to evaluate the role of interleukin-1 (IL-1) signaling as a target for pharmacological intervention. Male mice received a controlled cortical impact or sham surgery at postnatal day 21, approximating a toddler-aged child. Mice were treated acutely with an IL-1 receptor antagonist (IL-1Ra; 100 mg/kg, s.c.) or vehicle. Spontaneous and evoked seizures were evaluated from video-EEG recordings. Behavioral assays tested for functional outcomes, postmortem analyses assessed neuropathology, and brain atrophy was detected by ex vivo magnetic resonance imaging. At 2 weeks and 3 months post-injury, TBI mice showed an elevated seizure response to the convulsant pentylenetetrazol compared with sham mice, associated with abnormal hippocampal mossy fiber sprouting. A robust increase in IL-1β and IL-1 receptor were detected after TBI. IL-1Ra treatment reduced seizure susceptibility 2 weeks after TBI compared with vehicle, and a reduction in hippocampal astrogliosis. In a chronic study, IL-1Ra-TBI mice showed improved spatial memory at 4 months post-injury. At 5 months, most TBI mice exhibited spontaneous seizures during a 7 d video-EEG recording period. At 6 months, IL-1Ra-TBI mice had fewer evoked seizures compared with vehicle controls, coinciding with greater preservation of cortical tissue. Findings demonstrate this model's utility to delineate mechanisms underlying epileptogenesis after pediatric brain injury, and provide evidence of IL-1 signaling as a mediator of post-traumatic astrogliosis and seizure susceptibility.SIGNIFICANCE STATEMENT Epilepsy is a common cause of morbidity after traumatic brain injury in early childhood. However, a limited understanding of how epilepsy develops, particularly in the immature brain, likely contributes to the lack of efficacious treatments. In this preclinical study, we first demonstrate that a mouse model of traumatic injury to the pediatric brain reproduces many neuropathological and seizure-like hallmarks characteristic of epilepsy. Second, we demonstrate that targeting the acute inflammatory response reduces cognitive impairments, the degree of neuropathology, and seizure susceptibility, after pediatric brain injury in mice. These findings provide evidence that inflammatory cytokine signaling is a key process underlying epilepsy development after an acquired brain insult, which represents a feasible therapeutic target to improve quality of life for survivors.
Copyright © 2017 the authors 0270-6474/17/377864-14$15.00/0.

Entities:  

Keywords:  cytokine; interleukin; neurotrauma; pediatric; seizure; traumatic brain injury

Mesh:

Substances:

Year:  2017        PMID: 28724747      PMCID: PMC5559762          DOI: 10.1523/JNEUROSCI.0982-17.2017

Source DB:  PubMed          Journal:  J Neurosci        ISSN: 0270-6474            Impact factor:   6.167


  54 in total

1.  Post-traumatic early epilepsy in pediatric age group with emphasis on influential factors.

Authors:  Ozkan Ateş; Sevim Ondül; Cağatay Onal; Mehmet Büyükkiraz; Hakan Somay; Süleyman R Cayli; Mehmet A Göğüsgeren; Metin Orakdöğen; Ayhan Koçak; Saim Yoloğlu; Zafer Berkman; Mahir Tevrüz
Journal:  Childs Nerv Syst       Date:  2005-05-12       Impact factor: 1.475

2.  The model of pentylenetetrazol-induced status epilepticus in the immature rat: short- and long-term effects.

Authors:  A Nehlig; A Pereira de Vasconcelos
Journal:  Epilepsy Res       Date:  1996-12       Impact factor: 3.045

3.  Seizures and neuronal damage in mice lacking vesicular zinc.

Authors:  T B Cole; C A Robbins; H J Wenzel; P A Schwartzkroin; R D Palmiter
Journal:  Epilepsy Res       Date:  2000-04       Impact factor: 3.045

4.  The systemic kainic acid rat model of temporal lobe epilepsy: Long-term EEG monitoring.

Authors:  B Van Nieuwenhuyse; R Raedt; M Sprengers; I Dauwe; S Gadeyne; E Carrette; J Delbeke; W J Wadman; P Boon; K Vonck
Journal:  Brain Res       Date:  2015-09-14       Impact factor: 3.252

Review 5.  From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options.

Authors:  Asla Pitkänen; Riikka J Immonen; Olli H J Gröhn; Irina Kharatishvili
Journal:  Epilepsia       Date:  2009-02       Impact factor: 5.864

6.  Postnatal inflammation increases seizure susceptibility in adult rats.

Authors:  Michael A Galic; Kiarash Riazi; James G Heida; Abdeslam Mouihate; Neil M Fournier; Sarah J Spencer; Lisa E Kalynchuk; G Campbell Teskey; Quentin J Pittman
Journal:  J Neurosci       Date:  2008-07-02       Impact factor: 6.167

7.  Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort.

Authors:  Daniel H Arndt; Jason T Lerner; Joyce H Matsumoto; Andranik Madikians; Sue Yudovin; Hannah Valino; David L McArthur; Joyce Y Wu; Michelle Leung; Farzad Buxey; Conrad Szeliga; Michele Van Hirtum-Das; Raman Sankar; Amy Brooks-Kayal; Christopher C Giza
Journal:  Epilepsia       Date:  2013-09-13       Impact factor: 5.864

8.  Factors influencing posttraumatic seizures in children.

Authors:  Y S Hahn; S Fuchs; A M Flannery; M J Barthel; D G McLone
Journal:  Neurosurgery       Date:  1988-05       Impact factor: 4.654

9.  Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures.

Authors:  A Vezzani; M Conti; A De Luigi; T Ravizza; D Moneta; F Marchesi; M G De Simoni
Journal:  J Neurosci       Date:  1999-06-15       Impact factor: 6.167

Review 10.  Inflammation in epileptogenesis after traumatic brain injury.

Authors:  Kyria M Webster; Mujun Sun; Peter Crack; Terence J O'Brien; Sandy R Shultz; Bridgette D Semple
Journal:  J Neuroinflammation       Date:  2017-01-13       Impact factor: 8.322

View more
  34 in total

Review 1.  Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury.

Authors:  Jimmy W Huh; Ramesh Raghupathi
Journal:  Neuropharmacology       Date:  2018-06-20       Impact factor: 5.250

2.  Neuroinflammation and Seizures After Pediatric Brain Injury: What a Headache!

Authors:  Bret N Smith
Journal:  Epilepsy Curr       Date:  2018 Jul-Aug       Impact factor: 7.500

3.  Toll-Like Receptor 4 Knockdown Attenuates Brain Damage and Neuroinflammation After Traumatic Brain Injury via Inhibiting Neuronal Autophagy and Astrocyte Activation.

Authors:  Hongsheng Jiang; Yanzhou Wang; Xin Liang; Xiaofeng Xing; Xiuzhen Xu; Caifeng Zhou
Journal:  Cell Mol Neurobiol       Date:  2017-12-08       Impact factor: 5.046

Review 4.  Selective vulnerability of hippocampal interneurons to graded traumatic brain injury.

Authors:  Jan C Frankowski; Young J Kim; Robert F Hunt
Journal:  Neurobiol Dis       Date:  2018-07-19       Impact factor: 5.996

5.  Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice.

Authors:  Joon Yong Chung; Nicolas Krapp; Limin Wu; Sevda Lule; Lauren M McAllister; William J Edmiston; Samantha Martin; Emily Levy; Tanya Songtachalert; John S Sherwood; Erin M Buckley; Bharat Sanders; Saef Izzy; Suzanne Hickman; Shuzhen Guo; Josephine Lok; Joseph El Khoury; Eng H Lo; David Kaplan; Michael J Whalen
Journal:  J Neurotrauma       Date:  2018-08-03       Impact factor: 5.269

6.  Repetitive head injury in adolescent mice: A role for vascular inflammation.

Authors:  Limin Wu; Joon Y Chung; Shivani Saith; Lorenzo Tozzi; Erin M Buckley; Bharat Sanders; Maria A Franceschini; Sevda Lule; Saef Izzy; Josephine Lok; William J Edmiston; Lauren M McAllister; Sloane Mebane; Gina Jin; Jiaxi Lu; John S Sherwood; Sarah Willwerth; Suzanne Hickman; Joseph El Khoury; Eng H Lo; David Kaplan; Michael J Whalen
Journal:  J Cereb Blood Flow Metab       Date:  2018-07-13       Impact factor: 6.200

7.  Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury.

Authors:  Eugene Mironets; Patrick Osei-Owusu; Valerie Bracchi-Ricard; Roman Fischer; Elizabeth A Owens; Jerome Ricard; Di Wu; Tatiana Saltos; Eileen Collyer; Shaoping Hou; John R Bethea; Veronica J Tom
Journal:  J Neurosci       Date:  2018-04-02       Impact factor: 6.167

Review 8.  Converging early responses to brain injury pave the road to epileptogenesis.

Authors:  Eric J Neuberger; Akshay Gupta; Deepak Subramanian; Akshata A Korgaonkar; Vijayalakshmi Santhakumar
Journal:  J Neurosci Res       Date:  2017-11-29       Impact factor: 4.164

Review 9.  TBI Rehabilomics Research: Conceptualizing a humoral triad for designing effective rehabilitation interventions.

Authors:  A K Wagner; R G Kumar
Journal:  Neuropharmacology       Date:  2018-09-14       Impact factor: 5.250

10.  White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation.

Authors:  Akram Zamani; Terence J O'Brien; Jeff Kershaw; Leigh A Johnston; Bridgette D Semple; David K Wright
Journal:  Brain Imaging Behav       Date:  2021-01-07       Impact factor: 3.978

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.