Literature DB >> 2872399

Strategies for the prevention of malaria in travellers: comparison of drug regimens by means of risk-benefit analysis.

T E Peto, C F Gilks.   

Abstract

A risk-benefit analysis has been used to balance the risks to travellers of death from malaria against the toxicity of various drug regimens. The mortality of travellers who take no prophylaxis is estimated to be surprisingly low, and it is concluded that most travellers, even in areas of drug resistance should take only non-toxic drugs, such as a combination of chloroquine and proguanil.

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Year:  1986        PMID: 2872399     DOI: 10.1016/s0140-6736(86)91395-4

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  21 in total

1.  Prophylaxis against malaria.

Authors:  P R Barker; G A Hornett
Journal:  Br J Gen Pract       Date:  1992-07       Impact factor: 5.386

Review 2.  Ascertainment of risk of serious adverse reactions associated with chemoprophylactic antimalarial drugs.

Authors:  P A Phillips-Howard; A B Bjorkman
Journal:  Bull World Health Organ       Date:  1990       Impact factor: 9.408

3.  Serious adverse drug reactions to pyrimethamine-sulphadoxine, pyrimethamine-dapsone and to amodiaquine in Britain.

Authors:  P A Phillips-Howard; L J West
Journal:  J R Soc Med       Date:  1990-02       Impact factor: 5.344

Review 4.  Antimalarial agents: specific chemoprophylaxis regimens.

Authors:  B L Herwaldt; D J Krogstad; P H Schlesinger
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

Review 5.  Toxicity of antimalarial drugs.

Authors:  T E Peto
Journal:  J R Soc Med       Date:  1989       Impact factor: 5.344

Review 6.  Efficacy of drug prophylaxis.

Authors:  P A Phillips-Howard
Journal:  J R Soc Med       Date:  1989       Impact factor: 5.344

7.  Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.

Authors:  S A Ward; W M Watkins; E Mberu; J E Saunders; D K Koech; H M Gilles; R E Howells; A M Breckenridge
Journal:  Br J Clin Pharmacol       Date:  1989-06       Impact factor: 4.335

8.  Malaria prophylaxis with proguanil and sulfisoxazole in children living in a malaria endemic area.

Authors:  L W Pang; N Limsomwong; P Singharaj; C J Canfield
Journal:  Bull World Health Organ       Date:  1989       Impact factor: 9.408

Review 9.  Adverse effects of antimalarials. An update.

Authors:  G A Luzzi; T E Peto
Journal:  Drug Saf       Date:  1993-04       Impact factor: 5.606

10.  The multiple dose pharmacokinetics of proguanil.

Authors:  N A Helsby; G Edwards; A M Breckenridge; S A Ward
Journal:  Br J Clin Pharmacol       Date:  1993-06       Impact factor: 4.335

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