| Literature DB >> 2872294 |
M E Moro, M M Velazquez, J M Cachaza, L J Rodriguez.
Abstract
The solubility of diazepam and prazepam in aqueous polyoxyethylen-10-dodecanol, polyoxyethylen-23-dodecanol and polyoxyethylen-20-hexadecanol, has been determined at 25.0 degrees C. Diazepam seems to achieve a higher micellar penetration than prazepam, in spite of an expected smaller hydrophobic character. Thermodynamic interpretation of the micellar solutions is carried out using the regular solutions approach. A surfactant-independent relation between solubilities of both drugs has been derived.Entities:
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Year: 1986 PMID： 2872294 DOI： 10.1111/j.2042-7158.1986.tb04569.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765