| Literature DB >> 28722109 |
Yuan Fang1,2,3, Zhe Su4,5, Jing Xie6, Ruidong Xue4, Qi Ma4, Yanmeng Li4, Yifan Zhao4, Zeshi Song7, Xiongxiong Lu1,2, Hongwei Li2, Chenghong Peng1,2,3, Fan Bai4, Baiyong Shen1,2,3.
Abstract
In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells. Our study has updated genomic knowledge to help with understanding mixed cancers of the pancreas.Entities:
Keywords: 3p loss; TP53; mixed cancer; pancreatic adenosquamous carcinoma (PASC)
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Year: 2017 PMID： 28722109 DOI： 10.1002/path.4943
Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996