Literature DB >> 28721607

Access to High Cost Cancer Medicines Through the Lens of an Australian Senate Inquiry-Defining the "Goods" at Stake.

Narcyz Ghinea1, Miles Little2, Wendy Lipworth2.   

Abstract

Cancer is a major burden on populations and health systems internationally. The development of innovative cancer medicines is seen as a significant part of the solution. These new cancer medicines are, however, expensive, leading to limited or delayed access and disagreements among stakeholders about which medicines to fund. There is no obvious resolution to these disagreements, with stakeholders holding firmly to divergent positions. Access to cancer medicines was recently explored in Australia in a Senate Inquiry into the Availability of New, Innovative, and Specialist Cancer Drugs in Australia. We analysed the resultant Senate Report to identify competing stakeholder values. Our analysis illustrates that there are four main "goods" prioritized by different stakeholders: 1) innovation, 2) compassion, 3) equity, and 4) sustainability. We observe that, with the exception of sustainability, all of these "goods" put pressure on payers to provide access to cancer medicines more quickly and based on less rigorous evaluation processes. We then explore the consequences of giving in to such pressure and suggest that deconstructing the implicit values in calls for "enhanced access" to cancer medicines is necessary so that more nuanced solutions to the challenge of providing access to these high cost medicines can be found.

Entities:  

Keywords:  Cancer; Ethics; Funding; High cost drugs; Pharmaceuticals

Mesh:

Year:  2017        PMID: 28721607     DOI: 10.1007/s11673-017-9800-2

Source DB:  PubMed          Journal:  J Bioeth Inq        ISSN: 1176-7529            Impact factor:   1.352


  19 in total

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Authors:  G Mooney
Journal:  Int J Qual Health Care       Date:  2000-10       Impact factor: 2.038

2.  Cancer Drugs Approved on the Basis of a Surrogate End Point and Subsequent Overall Survival: An Analysis of 5 Years of US Food and Drug Administration Approvals.

Authors:  Chul Kim; Vinay Prasad
Journal:  JAMA Intern Med       Date:  2015-12       Impact factor: 21.873

3.  Unintended consequences of expensive cancer therapeutics—the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture.

Authors:  Tito Fojo; Sham Mailankody; Andrew Lo
Journal:  JAMA Otolaryngol Head Neck Surg       Date:  2014-12       Impact factor: 6.223

4.  Cancer drugs in the United States: Justum Pretium--the just price.

Authors:  Hagop M Kantarjian; Tito Fojo; Michael Mathisen; Leonard A Zwelling
Journal:  J Clin Oncol       Date:  2013-05-06       Impact factor: 44.544

Review 5.  Propaganda or the cost of innovation? Challenging the high price of new drugs.

Authors:  Narcyz Ghinea; Wendy Lipworth; Ian Kerridge
Journal:  BMJ       Date:  2016-03-11

6.  Pharmaceutical Policy Reform--Balancing Affordability with Incentives for Innovation.

Authors:  Rena M Conti; Meredith B Rosenthal
Journal:  N Engl J Med       Date:  2016-02-25       Impact factor: 91.245

7.  The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: from the perspective of a large group of CML experts.

Authors: 
Journal:  Blood       Date:  2013-04-25       Impact factor: 22.113

8.  In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Authors:  Ayalew Tefferi; Hagop Kantarjian; S Vincent Rajkumar; Lawrence H Baker; Jan L Abkowitz; John W Adamson; Ranjana Hira Advani; James Allison; Karen H Antman; Robert C Bast; John M Bennett; Edward J Benz; Nancy Berliner; Joseph Bertino; Ravi Bhatia; Smita Bhatia; Deepa Bhojwani; Charles D Blanke; Clara D Bloomfield; Linda Bosserman; Hal E Broxmeyer; John C Byrd; Fernando Cabanillas; George Peter Canellos; Bruce A Chabner; Asher Chanan-Khan; Bruce Cheson; Bayard Clarkson; Susan L Cohn; Gerardo Colon-Otero; Jorge Cortes; Steven Coutre; Massimo Cristofanilli; Walter J Curran; George Q Daley; Daniel J DeAngelo; H Joachim Deeg; Lawrence H Einhorn; Harry P Erba; Francisco J Esteva; Elihu Estey; Isaiah J Fidler; James Foran; Stephen Forman; Emil Freireich; Charles Fuchs; James N George; Morie A Gertz; Sergio Giralt; Harvey Golomb; Peter Greenberg; Jordan Gutterman; Robert I Handin; Samuel Hellman; Paulo Marcelo Hoff; Ronald Hoffman; Waun Ki Hong; Mary Horowitz; Gabriel N Hortobagyi; Clifford Hudis; Jean Pierre Issa; Bruce Evan Johnson; Philip W Kantoff; Kenneth Kaushansky; David Khayat; Fadlo R Khuri; Thomas J Kipps; Margaret Kripke; Robert A Kyle; Richard A Larson; Theodore S Lawrence; Ross Levine; Michael P Link; Scott M Lippman; Sagar Lonial; Gary H Lyman; Maurie Markman; John Mendelsohn; Neal J Meropol; Yoav Messinger; Therese M Mulvey; Susan O'Brien; Roman Perez-Soler; Raphael Pollock; Josef Prchal; Oliver Press; Jerald Radich; Kanti Rai; Saul A Rosenberg; Jacob M Rowe; Hope Rugo; Carolyn D Runowicz; Brenda M Sandmaier; Alan Saven; Andrew I Schafer; Charles Schiffer; Mikkael A Sekeres; Richard T Silver; Lillian L Siu; David P Steensma; F Marc Stewart; Wendy Stock; Richard Stone; Rainer Storb; Louise C Strong; Martin S Tallman; Michael Thompson; Naoto T Ueno; Richard A Van Etten; Julie M Vose; Peter H Wiernik; Eric P Winer; Anas Younes; Andrew D Zelenetz; Charles A LeMaistre
Journal:  Mayo Clin Proc       Date:  2015-07-23       Impact factor: 7.616

9.  Why the Shift? Taking a Closer Look at the Growing Interest in Niche Markets and Personalized Medicine.

Authors:  Shannon Gibson; Hamid R Raziee; Trudo Lemmens
Journal:  World Med Health Policy       Date:  2015-03

10.  Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment.

Authors:  Andrew Hill; Dzintars Gotham; Joseph Fortunak; Jonathan Meldrum; Isabelle Erbacher; Manuel Martin; Haitham Shoman; Jacob Levi; William G Powderly; Mark Bower
Journal:  BMJ Open       Date:  2016-01-27       Impact factor: 2.692

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  1 in total

1.  A 450 Year Old Turkish Poem, Art as a Qualitative Investigation Tool, Buddhist Deathways, Karma and Eudaimonia in Death and Organ Donation: The Wonders of Truly Diverse Bioethical Inquiry!

Authors:  Michael A Ashby
Journal:  J Bioeth Inq       Date:  2017-08-16       Impact factor: 1.352

  1 in total

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