| Literature DB >> 28721406 |
Yiqing Zhou1, Zhengao Di1, Xiaoming Li2, Yuanhong Shan3, Weichao Li1, Haibing Zhang4, Youli Xiao5.
Abstract
CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.Entities:
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Year: 2017 PMID： 28721406 DOI： 10.1039/c7cc04345g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222