Literature DB >> 28720546

The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer.

Xuerui Li1, Shuxia Wang2, Zhenzhong Li3, Xiaoyu Long4, Zibai Guo5, Guochun Zhang6, Jian Zu6, Yu Chen7, Linzhu Wen6.   

Abstract

Long non-coding RNAs play a significant role in cancer metastasis. Studies have demonstrated that LncRNA NEAT1 promotes cancer progression. We aimed to explore whether NEAT1 regulated growth and invasion in breast cancer cells. We provided evidence that lncRNA NEAT1 was up-regulated in breast cancer cell lines and tissues. NEAT1 promoted invasion through inducing Epithelial-mesenchymal transition (EMT) and NEAT1 played a role in 5-fluorouracil (5-FU) resistance. In addition, we revealed a reciprocal repression between NEAT1 and miR-211. Furthermore, the EMT-inducer HMGA2 was identified as a down-stream target of miR-211. LncRNA NEAT1 induced EMT and 5-FU resistance through the miR-211/HMGA2 axis. Our findings suggest that lncRNA NEAT1 could be a new diagnostic biomarker and therapy target for breast cancer.
Copyright © 2017. Published by Elsevier B.V.

Entities:  

Keywords:  HMGA2; NEAT1; miR-211

Mesh：

Substances：

Year:  2017        PMID： 28720546     DOI： 10.1016/j.ijbiomac.2017.07.053

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  55 in total

1.  miRNA-211 stops the clock.

Authors:  Carmit Levy; Tamar Golan; David E Fisher
Journal:  Noncoding RNA Investig       Date:  2018-05-06

2.  The protective role of miR-132 targeting HMGA2 through the PI3K/AKT pathway in mice with Alzheimer's disease.

Authors:  Xichang Liu; Haitao Wang; Jiawei Bei; Jun Zhao; Ge Jiang; Xiuhong Liu
Journal:  Am J Transl Res       Date:  2021-05-15       Impact factor: 4.060

3.  LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer.

Authors:  Meihua Liang; Jinliang Jia; Lili Chen; Biyue Wei; Qiang Guan; Zhaoming Ding; Jiawei Yu; Rui Pang; Guoqing He
Journal:  Endocrine       Date:  2019-04-27       Impact factor: 3.633

4.  Long noncoding RNA LINC00963 promotes breast cancer progression by functioning as a molecular sponge for microRNA-625 and thereby upregulating HMGA1.

Authors:  Zhen Wu; Wei Wang; Yongkun Wang; Xin Wang; Shanping Sun; Yumin Yao; Yang Zhang; Zhongxi Ren
Journal:  Cell Cycle       Date:  2020-02-13       Impact factor: 4.534

5.  A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.

Authors:  Rasoul Abdollahzadeh; Asaad Azarnezhad; Sahereh Paknahad; Yaser Mansoori; Maryam Pirhoushiaran; Khaled Kanaani; Neda Bafandeh; Davood Jafari; Javad Tavakkoly-Bazzaz
Journal:  Biochem Genet       Date:  2022-03-17       Impact factor: 1.890

6.  ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform.

Authors:  Christiane Klec; Erik Knutsen; Daniela Schwarzenbacher; Katharina Jonas; Barbara Pasculli; Ellen Heitzer; Beate Rinner; Katarina Krajina; Felix Prinz; Benjamin Gottschalk; Peter Ulz; Alexander Deutsch; Andreas Prokesch; Stephan W Jahn; S Mohammad Lellahi; Maria Perander; Raffaela Barbano; Wolfgang F Graier; Paola Parrella; George Adrian Calin; Martin Pichler
Journal:  Cell Mol Life Sci       Date:  2022-07-01       Impact factor: 9.207

7.  CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis.

Authors:  Mingzhi Zhu; Yanyan Wang; Fang Wang; Lin Li; Xinguang Qiu
Journal:  Cancer Cell Int       Date:  2021-07-19       Impact factor: 5.722

8.  Long Non-coding RNA NEAT1 as an Emerging Biomarker in Breast and Gynecologic Cancers: a Systematic Overview.

Authors:  Sanu Thankachan; Boddapati Kalyani Bhardwaj; Thejaswini Venkatesh; Padmanaban S Suresh
Journal:  Reprod Sci       Date:  2021-02-10       Impact factor: 3.060

9.  LncRNA NEAT1 Acts as an miR-148b-3p Sponge to Regulate ROCK1 Inhibition of Retinoblastoma Growth.

Authors:  Hang Lu; Zhenjun Zhang; Yao Lu; Weiwei Xiu; Jinglin Cui
Journal:  Cancer Manag Res       Date:  2021-07-12       Impact factor: 3.989

10.  Downregulation of NEAT1 reverses the radioactive iodine resistance of papillary thyroid carcinoma cell via miR-101-3p/FN1/PI3K-AKT signaling pathway.

Authors:  Chao Liu; Zhiping Feng; Ting Chen; Juan Lv; Pengjie Liu; Li Jia; Jialun Zhu; Fukun Chen; Chuanzhou Yang; Zhiyong Deng
Journal:  Cell Cycle       Date:  2018-12-30       Impact factor: 5.173
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.