Literature DB >> 2872031

Glutathione conjugates. Immobilized enzyme synthesis and characterization by fast atom bombardment mass spectrometry.

S L Pallante, C A Lisek, D M Dulik, C Fenselau.   

Abstract

Glutathione transferase activity was shown to be present in an immobilized preparation of microsomal protein. Chlorodinitrobenzene, ethacrynic acid, captopril, styrene oxide, and iminocyclophosphamide were found to be substrates, each providing a different kind of electrophilic functional group for conjugation. The glutathione conjugates were characterized by thin layer chromatography (visualized by reaction with ninhydrin) and by high pressure liquid chromatography. A variety of conditions was evaluated for analysis of these glutathiones by fast atom bombardment mass spectrometry.

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Year:  1986        PMID： 2872031

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN： 0090-9556            Impact factor:   3.922


  6 in total

Review 1.  Glutathione, glutathione S-transferase, and glutathione conjugates, complementary markers of oxidative stress in aquatic biota.

Authors:  Jocelyne Hellou; Neil W Ross; Thomas W Moon
Journal:  Environ Sci Pollut Res Int       Date:  2012-04-25       Impact factor: 4.223

2.  Preparation of diastereomeric beta-d-glucuronides of the bronchodilator procaterol using immobilized rabbit liver microsomal enzymes.

Authors:  T F Woolf; T Chang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Apr-Jun       Impact factor: 2.441

3.  Fragmentation characteristic of glutathione conjugates activated by high-energy collisions.

Authors:  C M Murphy; C Fenselau; P L Gutierrez
Journal:  J Am Soc Mass Spectrom       Date:  1992-11       Impact factor: 3.109

4.  Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.

Authors:  M A Alaoui-Jamali; L Panasci; G M Centurioni; R Schecter; S Lehnert; G Batist
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

5.  Immobilization of microsomes into alginate beads is a convenient method for producing glucuronides from drugs.

Authors:  M Haumont; J Magdalou; J C Ziegler; R Bidault; J P Siest; G Siest
Journal:  Appl Microbiol Biotechnol       Date:  1991-07       Impact factor: 4.813

6.  Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide.

Authors:  K D Ballard; M J Raftery; H Jaeschke; S J Gaskell
Journal:  J Am Soc Mass Spectrom       Date:  1991-01       Impact factor: 3.109
  6 in total

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