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Literature DB >> 2872022

Cholinergic stimulation of human pancreatic secretion.

Abstract

The effect of graded doses of bethanechol on pancreatic secretion and plasma levels of pancreatic polypeptide and somatostatin was investigated in six healthy volunteers. In other studies the effect of a bethanechol background on the secretin-CCK stimulation of pancreatic secretion was also studied. Bethanechol caused a moderate stimulation of amylase secretion with a weak stimulation of bicarbonate secretion. These effects were not associated with significant changes in the plasma level of pancreatic polypeptide and somatostatin. Bethanechol enhanced the response to secretin and CCK. These results confirm a cholinergic pathway in the stimulation of pancreatic secretion in man.

Entities: Chemical Disease Gene Species

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Year: 1986 PMID： 2872022 DOI： 10.1007/bf01318692

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

16 in total

1. Relation of secretin to the parasympathetic mechanism for pancreatic secretion.

Authors: T M LIN; A C IVY
Journal: Am J Physiol Date: 1957-05

2. Cholinergic secretory and inhibitory mechanisms in canine pancreatic secretion.

Authors: D N Schmidt; H Sarles; T M Biedzinski; M A Devaux
Journal: Scand J Gastroenterol Date: 1981-04 Impact factor: 2.423

3. Automated method for determining amylase activity in serum and urine.

Authors: A Mazzuchin; C Weggel; C J Porter
Journal: Clin Chem Date: 1973-10 Impact factor: 8.327

4. Cephalic phase of pancreatic secretion in man.

Authors: H Sarles; R Dani; G Prezelin; C Souville; C Figarella
Journal: Gut Date: 1968-04 Impact factor: 23.059

5. Failure of urecholine to potentiate the pancreatic response to exogenous stimuli.

Authors: R M Preshaw; K Adashek; A R Cooke; M I Grossman
Journal: Proc Soc Exp Biol Med Date: 1965 Aug-Sep

6. Somatostatin-like immunoreactivity in the retina.

Authors: T Yamada; D Marshak; S Basinger; J Walsh; J Morley; W Stell
Journal: Proc Natl Acad Sci U S A Date: 1980-03 Impact factor: 11.205

7. Effect of acetylcholine on the release of pancreatic and gastric somatostatin-like immunoreactivity in normal, chemically sympathectomized and indomethacin-treated dogs.

Authors: V Schusdziarra; W Stapelfeldt; M Klier; E F Pfeiffer
Journal: Hepatogastroenterology Date: 1982-08

Cholinergic stimulation of human pancreatic secretion.

1. Relation of secretin to the parasympathetic mechanism for pancreatic secretion.

2. Cholinergic secretory and inhibitory mechanisms in canine pancreatic secretion.

3. Automated method for determining amylase activity in serum and urine.

4. Cephalic phase of pancreatic secretion in man.

5. Failure of urecholine to potentiate the pancreatic response to exogenous stimuli.

6. Somatostatin-like immunoreactivity in the retina.

7. Effect of acetylcholine on the release of pancreatic and gastric somatostatin-like immunoreactivity in normal, chemically sympathectomized and indomethacin-treated dogs.

8. Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion.

9. Cholinergic component in the human pancreatic secretory response to intraintestinal oleate.

10. Pancreatic secretory response to sham feeding in humans.

Review 1. Structure and function of the exocrine pancreas in patients with type 1 diabetes.

2. Studies of the role of opioids in control of human pancreatic secretion.

3. Isolation and monolayer culture of guinea pig pancreatic duct epithelial cells.

4. Impaired exocrine pancreatic function in diabetics with diarrhea and peripheral neuropathy.