BACKGROUND AND OBJECTIVE: In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. However, the association between inflammation, cognitive impairment, and cerebrospinal biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio) is poorly understood. METHODS: A large panel of inflammatory cytokines (interleukin [IL]-1β, IL-1ra, IL-2, IL-4, IL-6, IL-10, IL-17, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor) was analyzed using a multiplex immunoassay in 27 patients with a diagnosis of AD dementia and in 18 control subjects. In a subgroup with available cerebrospinal fluid (CSF) samples, cytokines in serum were correlated with the levels of neurodegenerative CSF biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio). RESULTS: Compared to control subjects, AD patients showed a significant upregulation of IL-10, IL-1β, and IL-17 serum levels. Several cytokines appeared intercorrelated, and IL-10 in particular presented a significant inverse correlation with CFS levels of Aβ42 and the Aβ42/p-tau ratio. CONCLUSION: Our findings indicate that serum levels of IL-10 may represent a possible peripheral expression of amyloid beta deposition in AD patients.
BACKGROUND AND OBJECTIVE: In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. However, the association between inflammation, cognitive impairment, and cerebrospinal biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio) is poorly understood. METHODS: A large panel of inflammatory cytokines (interleukin [IL]-1β, IL-1ra, IL-2, IL-4, IL-6, IL-10, IL-17, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor) was analyzed using a multiplex immunoassay in 27 patients with a diagnosis of AD dementia and in 18 control subjects. In a subgroup with available cerebrospinal fluid (CSF) samples, cytokines in serum were correlated with the levels of neurodegenerative CSF biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio). RESULTS: Compared to control subjects, ADpatients showed a significant upregulation of IL-10, IL-1β, and IL-17 serum levels. Several cytokines appeared intercorrelated, and IL-10 in particular presented a significant inverse correlation with CFS levels of Aβ42 and the Aβ42/p-tau ratio. CONCLUSION: Our findings indicate that serum levels of IL-10 may represent a possible peripheral expression of amyloid beta deposition in ADpatients.
Authors: Timo Jan Oberstein; Lava Taha; Philipp Spitzer; Janina Hellstern; Martin Herrmann; Johannes Kornhuber; Juan Manuel Maler Journal: Front Immunol Date: 2018-06-04 Impact factor: 7.561
Authors: Jefferson W Kinney; Shane M Bemiller; Andrew S Murtishaw; Amanda M Leisgang; Arnold M Salazar; Bruce T Lamb Journal: Alzheimers Dement (N Y) Date: 2018-09-06
Authors: Carla M Startin; Nicholas J Ashton; Sarah Hamburg; Rosalyn Hithersay; Frances K Wiseman; Kin Y Mok; John Hardy; Alberto Lleó; Simon Lovestone; Lucilla Parnetti; Henrik Zetterberg; Abdul Hye; André Strydom Journal: Alzheimers Res Ther Date: 2019-03-21 Impact factor: 6.982
Authors: Samir Abu-Rumeileh; Petra Steinacker; Barbara Polischi; Angela Mammana; Anna Bartoletti-Stella; Patrick Oeckl; Simone Baiardi; Corrado Zenesini; André Huss; Pietro Cortelli; Sabina Capellari; Markus Otto; Piero Parchi Journal: Alzheimers Res Ther Date: 2019-12-31 Impact factor: 6.982