Johad Khoury1, Majd Arow2, Adi Elias1, Badira F Makhoul1, Gidon Berger1, Marielle Kaplan3, Tanya Mashiach4, Reem Ismael-Badarneh5, Doron Aronson6, Zaher S Azzam7. 1. Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel. 2. Ruth & Bruce Rappaport Faculty of Medicine, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel. 3. The Laboratory of Clinical Biochemistry, Rambam Health Care Campus, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel. 4. Statistics Service, Rambam Health Care Campus, Haifa, Israel. 5. Ruth & Bruce Rappaport Faculty of Medicine, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel; The Rappaport Family, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel. 6. Heart Institute, Rambam Health Care Campus, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel. 7. Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel; The Rappaport Family, Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, Haifa, Israel. Electronic address: z_azzam@rambam.health.gov.il.
Abstract
OBJECTIVES: Sepsis is a multifactorial syndrome with increasing incidence of morbidity and mortality. Identification of outcome predictors is therefore essential. Recently, elevated brain natriuretic peptide (BNP) levels have been observed in patients with septic shock. Little information is available concerning BNP levels in patients with critical illness, especially with sepsis. Therefore, this study aims to evaluate the role of BNP as a biomarker for long-term mortality in patients with sepsis. METHODS: We studied 259 patients with sepsis and absence of heart failure. BNP levels were obtained for all patients. A long-term survival follow-up was done, and survival was evaluated 90days after admission, and during the subsequent 60months of follow-up. RESULTS: Eighty-two patients died during the 90-day follow-up (31.7%), 53 died in the index hospitalization (20.5%). On multivariate analysis models, elevated values of BNP were a strong predictor of in-hospital mortality, 90-day and 60-month mortality in patients with sepsis. BNP was a better prognostic predictor than the Sepsis-related Organ Failure Assessment (SOFA) score for 90-day mortality, and a better predictor for 60-month mortality in low risk groups. CONCLUSION: In the population of hospitalized patients with sepsis, BNP is a strong independent predictor of short- and long-term mortality.
OBJECTIVES:Sepsis is a multifactorial syndrome with increasing incidence of morbidity and mortality. Identification of outcome predictors is therefore essential. Recently, elevated brain natriuretic peptide (BNP) levels have been observed in patients with septic shock. Little information is available concerning BNP levels in patients with critical illness, especially with sepsis. Therefore, this study aims to evaluate the role of BNP as a biomarker for long-term mortality in patients with sepsis. METHODS: We studied 259 patients with sepsis and absence of heart failure. BNP levels were obtained for all patients. A long-term survival follow-up was done, and survival was evaluated 90days after admission, and during the subsequent 60months of follow-up. RESULTS: Eighty-two patients died during the 90-day follow-up (31.7%), 53 died in the index hospitalization (20.5%). On multivariate analysis models, elevated values of BNP were a strong predictor of in-hospital mortality, 90-day and 60-month mortality in patients with sepsis. BNP was a better prognostic predictor than the Sepsis-related Organ Failure Assessment (SOFA) score for 90-day mortality, and a better predictor for 60-month mortality in low risk groups. CONCLUSION: In the population of hospitalized patients with sepsis, BNP is a strong independent predictor of short- and long-term mortality.
Authors: Carlo Custodero; Quran Wu; Gabriela L Ghita; Stephen D Anton; Scott C Brakenridge; Babette A Brumback; Philip A Efron; Anna K Gardner; Christiaan Leeuwenburgh; Lyle L Moldawer; John W Petersen; Frederick A Moore; Robert T Mankowski Journal: Crit Care Date: 2019-06-24 Impact factor: 9.097
Authors: Saarwaani Vallabhajosyula; Zhen Wang; M Hassan Murad; Shashaank Vallabhajosyula; Pranathi R Sundaragiri; Kianoush Kashani; Wayne L Miller; Allan S Jaffe; Saraschandra Vallabhajosyula Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2020-01-08
Authors: Francisco Martín-Rodríguez; Laura Melero-Guijarro; Guillermo J Ortega; Ancor Sanz-García; Teresa de la Torre de Dios; Jesús Álvarez Manzanares; José L Martín-Conty; Miguel A Castro Villamor; Juan F Delgado Benito; Raúl López-Izquierdo Journal: Dis Markers Date: 2022-02-23 Impact factor: 3.434