Literature DB >> 2871898

Peptides derived from prodynorphin are decreased in basal ganglia of Huntington's disease brains.

D Dawbarn, N Zamir, C M Waters, S P Hunt, P C Emson, M J Brownstein.   

Abstract

The contents of methionine-enkephalin-Arg-Gly-Leu, dynorphin A, dynorphin B and alpha-neoendorphin have been measured in both control and Huntington's disease brains obtained postmortem. All 4 peptides were significantly reduced in the caudate nucleus and putamen of Huntington's disease compared with the control group. No differences were observed in frontal cortex or hypothalamus. Immunocytochemistry showed a marked depletion of dynorphin-like immunoreactivity in Huntington's disease substantia nigra.

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Year:  1986        PMID： 2871898     DOI： 10.1016/0006-8993(86)91469-1

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  3 in total

1.  Oxidative stress and plasma aminopeptidase activity in Huntington's disease.

Authors:  Raquel Duran; Francisco J Barrero; Blas Morales; Juan D Luna; Manuel Ramirez; Francisco Vives
Journal:  J Neural Transm (Vienna)       Date:  2010-01-22       Impact factor: 3.575

2.  Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington's and Parkinson's disease.

Authors:  Peggy Barschke; Samir Abu-Rumeileh; M H D Rami Al Shweiki; Lorenzo Barba; Federico Paolini Paoletti; Patrick Oeckl; Petra Steinacker; Steffen Halbgebauer; Lorenzo Gaetani; Jan Lewerenz; Albert Christian Ludolph; Georg Bernhard Landwehrmeyer; Lucilla Parnetti; Markus Otto
Journal:  J Neurol       Date:  2022-06-23       Impact factor: 6.682

3.  Turning the 'Tides on Neuropsychiatric Diseases: The Role of Peptides in the Prefrontal Cortex.

Authors:  Dakota F Brockway; Nicole A Crowley
Journal:  Front Behav Neurosci       Date:  2020-10-20       Impact factor: 3.558
  3 in total

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