| Literature DB >> 28718684 |
Shelly Jain1, Preety Ghanghas1, Chandan Rana1, S N Sanyal1.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive agents because of their ability in blocking cellular proliferation, and thereby tumor development, and also by promoting apoptosis. GSK-3β, a serine threonine kinase and a negative regulator of the oncogenic Wnt/β-catenin signaling pathway, plays a critical role in the regulation of oncogenesis. Celecoxib and etoricoxib, the two cyclooxygenase-2 (COX-2) selective NSAIDs, and Diclofenac, a preferential COX-2 inhibitory NSAID, had shown uniformly the chemopreventive and anti-neoplastic effects in the early stage of colon cancer by promoting apoptosis as well as an over-expression of GSK-3β while down-regulating the PI3-K/Akt oncogenic pathway.Entities:
Keywords: Akt; DMH; GSK-3β; PI3-K; colorectal cancer; β-catenin
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Year: 2017 PMID： 28718684 DOI： 10.1080/07357907.2017.1337783
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176