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Literature DB >> 28718442

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment.

Abstract

Cancer cells are addicted to a large spectrum of extracellular cues implicated in initiation, stem cell renewal, tumor growth, dissemination in the body, and resistance to treatment. Wingless/Int-1 (Wnt) ligands and their associated signaling cascades contribute to most of these processes, paving the way for opportunities in therapeutic development. The developmental Wnt/planar cell polarity (PCP) pathway is the most recently described branch of Wnt signaling strongly implicated in cancer development at early and late stages. We describe here some of the latest knowledge accumulated on this pathway and the pending questions, present the most convincing findings about its role in cancer, and review the most promising strategies currently designed to target its components.

Entities: Disease Gene

Mesh：

Substances：
Wnt Proteins

Year: 2017 PMID： 28718442 DOI： 10.1016/j.trecan.2017.01.001

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

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Cited

21 in total

Review 1. Mixed signals from the cell's antennae: primary cilia in cancer.

Authors: Thibaut Eguether; Michael Hahne
Journal: EMBO Rep Date: 2018-10-22 Impact factor: 8.807

Review 2. The physiological role of Wnt pathway in normal development and cancer.

Authors: Xiang Li; Maria A Ortiz; Leszek Kotula
Journal: Exp Biol Med (Maywood) Date: 2020-01-29

3. Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

Authors: Madeline N Hayes; Karin McCarthy; Alexander Jin; Mariana L Oliveira; Sowmya Iyer; Sara P Garcia; Sivasish Sindiri; Berkley Gryder; Zainab Motala; G Petur Nielsen; Jean-Paul Borg; Matt van de Rijn; David Malkin; Javed Khan; Myron S Ignatius; David M Langenau
Journal: Cell Stem Cell Date: 2018-03-01 Impact factor: 24.633

4. Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Authors: Miroslav Micka; Vítězslav Bryja
Journal: Handb Exp Pharmacol Date: 2021

5. Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1^-/- mouse model of congenital hepatic fibrosis.

Authors: Luca Fabris; Chiara Milani; Romina Fiorotto; Valeria Mariotti; Eleanna Kaffe; Barbara Seller; Aurelio Sonzogni; Mario Strazzabosco; Massimiliano Cadamuro
Journal: FASEB J Date: 2022-06 Impact factor: 5.834

Review 10. Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications.

Authors: Anjali P Patni; M K Harishankar; Joel P Joseph; Bhuvanadas Sreeshma; Rama Jayaraj; Arikketh Devi
Journal: Cell Oncol (Dordr) Date: 2021-03-11 Impact factor: 6.730

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment.

Review 1. Mixed signals from the cell's antennae: primary cilia in cancer.

Review 2. The physiological role of Wnt pathway in normal development and cancer.

3. Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

4. Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

5. Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1^-/- mouse model of congenital hepatic fibrosis.

Review 6. Intratumor microbiome in cancer progression: current developments, challenges and future trends.

Review 7. The Role of DACT Family Members in Tumorigenesis and Tumor Progression.

Review 8. Contribution of the Wnt Pathway to Defining Biology of Glioblastoma.

9. EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells.

Review 10. Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications.

Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment.

Review 1. Mixed signals from the cell's antennae: primary cilia in cancer.

Review 2. The physiological role of Wnt pathway in normal development and cancer.

3. Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma.

4. Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

5. Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1-/- mouse model of congenital hepatic fibrosis.

Review 6. Intratumor microbiome in cancer progression: current developments, challenges and future trends.

Review 7. The Role of DACT Family Members in Tumorigenesis and Tumor Progression.

Review 8. Contribution of the Wnt Pathway to Defining Biology of Glioblastoma.

9. EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells.

Review 10. Comprehending the crosstalk between Notch, Wnt and Hedgehog signaling pathways in oral squamous cell carcinoma - clinical implications.

5. Dysregulation of the Scribble/YAP/β-catenin axis sustains the fibroinflammatory response in a PKHD1^-/- mouse model of congenital hepatic fibrosis.