Literature DB >> 28718435

Agrin to YAP in Cancer and Neuromuscular Junctions.

Wen-Cheng Xiong1, Lin Mei2.   

Abstract

Agrin is utilized by motor neurons to stimulate the LRP4-MuSK receptor in muscles for neuromuscular junction (NMJ) formation. Recent studies of cancer have identified novel functions of the low-density lipoprotein receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway. Agrin may act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4-MuSK pathway and integrin-focal adhesion pathway. Ensuing Yes-associated protein (YAP) activation promotes hepatocellular carcinoma (HCC). Here, we discuss the implications of the converged pathways in NMJ formation and liver cancer.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Agrin; LRP4; MuSK; YAP; liver cancer; neuromuscular junction

Mesh：

Substances：

Year:  2017        PMID： 28718435      PMCID： PMC5518631          DOI： 10.1016/j.trecan.2017.03.005

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  9 in total

1.  Structural basis of agrin-LRP4-MuSK signaling.

Authors:  Yinong Zong; Bin Zhang; Shenyan Gu; Kwangkook Lee; Jie Zhou; Guorui Yao; Dwight Figueiredo; Kay Perry; Lin Mei; Rongsheng Jin
Journal:  Genes Dev       Date:  2012-02-01       Impact factor: 11.361

Review 2.  To build a synapse: signaling pathways in neuromuscular junction assembly.

Authors:  Haitao Wu; Wen C Xiong; Lin Mei
Journal:  Development       Date:  2010-04       Impact factor: 6.868

3.  Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.

Authors:  Sayan Chakraborty; Kizito Njah; Ajaybabu V Pobbati; Ying Bena Lim; Anandhkumar Raju; Manikandan Lakshmanan; Vinay Tergaonkar; Chwee Teck Lim; Wanjin Hong
Journal:  Cell Rep       Date:  2017-03-07       Impact factor: 9.423

Review 4.  LRP4 in neuromuscular junction and bone development and diseases.

Authors:  Chengyong Shen; Wen-Cheng Xiong; Lin Mei
Journal:  Bone       Date:  2015-06-10       Impact factor: 4.398

5.  Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation.

Authors:  Lei Li; Yu Cao; Haitao Wu; Xinchun Ye; Zhihui Zhu; Guanglin Xing; Chengyong Shen; Arnab Barik; Bin Zhang; Xiaoling Xie; Wenbo Zhi; Lin Gan; Huabo Su; Wen-Cheng Xiong; Lin Mei
Journal:  Neuron       Date:  2016-11-10       Impact factor: 17.173

6.  LRP4 serves as a coreceptor of agrin.

Authors:  Bin Zhang; Shiwen Luo; Qiang Wang; Tatsuo Suzuki; Wen C Xiong; Lin Mei
Journal:  Neuron       Date:  2008-10-23       Impact factor: 17.173

7.  Lrp4 is a receptor for Agrin and forms a complex with MuSK.

Authors:  Natalie Kim; Amy L Stiegler; Thomas O Cameron; Peter T Hallock; Andrea M Gomez; Julie H Huang; Stevan R Hubbard; Michael L Dustin; Steven J Burden
Journal:  Cell       Date:  2008-10-09       Impact factor: 41.582

8.  An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma.

Authors:  Sayan Chakraborty; Manikandan Lakshmanan; Hannah L F Swa; Jianxiang Chen; Xiaoqian Zhang; Yan Shan Ong; Li Shen Loo; Semih Can Akıncılar; Jayantha Gunaratne; Vinay Tergaonkar; Kam M Hui; Wanjin Hong
Journal:  Nat Commun       Date:  2015-01-29       Impact factor: 14.919

9.  Lrp4 in astrocytes modulates glutamatergic transmission.

Authors:  Xiang-Dong Sun; Lei Li; Fang Liu; Zhi-Hui Huang; Jonathan C Bean; Hui-Feng Jiao; Arnab Barik; Seon-Myung Kim; Haitao Wu; Chengyong Shen; Yun Tian; Thiri W Lin; Ryan Bates; Anupama Sathyamurthy; Yong-Jun Chen; Dong-Min Yin; Lei Xiong; Hui-Ping Lin; Jin-Xia Hu; Bao-Ming Li; Tian-Ming Gao; Wen-Cheng Xiong; Lin Mei
Journal:  Nat Neurosci       Date:  2016-06-13       Impact factor: 24.884
  9 in total
  8 in total

1.  Microenvironment stiffness requires decellularized cardiac extracellular matrix to promote heart regeneration in the neonatal mouse heart.

Authors:  Xinming Wang; Subhadip Senapati; Akinola Akinbote; Bhargavee Gnanasambandam; Paul S-H Park; Samuel E Senyo
Journal:  Acta Biomater       Date:  2020-06-23       Impact factor: 8.947

2.  Agrin expression is correlated with tumor development and poor prognosis in cholangiocarcinoma.

Authors:  Meimei He; Chen Cheng; Junxue Tu; Sha-Sha Ji; Dan Lou; Binglong Bai
Journal:  J Int Med Res       Date:  2021-05       Impact factor: 1.671

3.  Agrin-Mediated Cardiac Regeneration: Some Open Questions.

Authors:  Maria Giulia Bigotti; Katie L Skeffington; Ffion P Jones; Massimo Caputo; Andrea Brancaccio
Journal:  Front Bioeng Biotechnol       Date:  2020-06-16

Review 4.  Cancer Cell Glycocalyx and Its Significance in Cancer Progression.

Authors:  Hongyan Kang; Qiuhong Wu; Anqiang Sun; Xiao Liu; Yubo Fan; Xiaoyan Deng
Journal:  Int J Mol Sci       Date:  2018-08-22       Impact factor: 5.923

Review 5.  The Cross-Talk Between the TNF-α and RASSF-Hippo Signalling Pathways.

Authors:  Delvac Oceandy; Bella Amanda; Faisal Yusuf Ashari; Zakiyatul Faizah; M Aminudin Azis; Nicholas Stafford
Journal:  Int J Mol Sci       Date:  2019-05-11       Impact factor: 5.923

Review 6.  Nerve, Muscle, and Synaptogenesis.

Authors:  Lauren Eric Swenarchuk
Journal:  Cells       Date:  2019-11-16       Impact factor: 6.600

Review 7.  Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond.

Authors:  Sayan Chakraborty; Wanjin Hong
Journal:  Cancers (Basel)       Date:  2018-02-06       Impact factor: 6.639

8.  Uncovering Prognosis-Related Genes and Pathways by Multi-Omics Analysis in Lung Cancer.

Authors:  Ken Asada; Kazuma Kobayashi; Samuel Joutard; Masashi Tubaki; Satoshi Takahashi; Ken Takasawa; Masaaki Komatsu; Syuzo Kaneko; Jun Sese; Ryuji Hamamoto
Journal:  Biomolecules       Date:  2020-03-30
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.