| Literature DB >> 28718422 |
Lorenzo Galluzzi1, Guido Kroemer2.
Abstract
Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.Entities:
Keywords: DFNA5; GSDMD; caspases; danger signaling; necroptosis; pyroptosis
Mesh:
Substances:
Year: 2017 PMID: 28718422 DOI: 10.1016/j.trecan.2016.12.001
Source DB: PubMed Journal: Trends Cancer ISSN: 2405-8025