Literature DB >> 28718401

Targeting ATF5 in Cancer.

James M Angelastro1.   

Abstract

The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer. ATF5 is important for the survival and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have recently shown efficacy against brain, breast, melanoma, and prostate cancers.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ATF5; CP-d/n-ATF5; apoptosis; cancer; cell-penetrating peptide; dominant negative

Mesh：

Substances：

Year:  2017        PMID： 28718401      PMCID： PMC5646417          DOI： 10.1016/j.trecan.2017.05.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  12 in total

1.  p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival.

Authors:  David X Liu; Dongmeng Qian; Bin Wang; Jin-Ming Yang; Zhimin Lu
Journal:  Mol Cell Biol       Date:  2011-07-26       Impact factor: 4.272

2.  ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells.

Authors:  Aiping Chen; Dongmeng Qian; Bin Wang; Ming Hu; Jinrong Lu; Yani Qi; David X Liu
Journal:  Int J Gynecol Pathol       Date:  2012-11       Impact factor: 2.762

3.  Attractive interhelical electrostatic interactions in the proline- and acidic-rich region (PAR) leucine zipper subfamily preclude heterodimerization with other basic leucine zipper subfamilies.

Authors:  J R Moll; M Olive; C Vinson
Journal:  J Biol Chem       Date:  2000-11-03       Impact factor: 5.157

4.  Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.

Authors:  Xijun Liu; Dan Liu; Dongmeng Qian; Jenny Dai; Yi An; Shaoyan Jiang; Bruce Stanley; Jinming Yang; Bin Wang; Xinyuan Liu; David X Liu
Journal:  J Biol Chem       Date:  2012-04-23       Impact factor: 5.157

5.  A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

Authors:  Zhi Sheng; Li Li; Lihua J Zhu; Thomas W Smith; Andrea Demers; Alonzo H Ross; Richard P Moser; Michael R Green
Journal:  Nat Med       Date:  2010-05-23       Impact factor: 53.440

Review 6.  The transcription factor ATF5: role in neurodevelopment and neural tumors.

Authors:  Lloyd A Greene; Hae Young Lee; James M Angelastro
Journal:  J Neurochem       Date:  2008-11-15       Impact factor: 5.372

7.  A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers.

Authors:  Georg Karpel-Massler; Basil A Horst; Chang Shu; Lily Chau; Takashi Tsujiuchi; Jeffrey N Bruce; Peter Canoll; Lloyd A Greene; James M Angelastro; Markus D Siegelin
Journal:  Clin Cancer Res       Date:  2016-04-28       Impact factor: 12.531

8.  Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas.

Authors:  A Arias; M W Lamé; L Santarelli; R Hen; L A Greene; J M Angelastro
Journal:  Oncogene       Date:  2011-07-04       Impact factor: 9.867

9.  Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide.

Authors:  Charles C Cates; Angelo D Arias; Lynn S Nakayama Wong; Michael W Lamé; Maxim Sidorov; Geraldine Cayanan; Douglas J Rowland; Jennifer Fung; Georg Karpel-Massler; Markus D Siegelin; Lloyd A Greene; James M Angelastro
Journal:  Oncotarget       Date:  2016-03-15

10.  Transcriptomic and functional pathways analysis of ascorbate-induced cytotoxicity and resistance of Burkitt lymphoma.

Authors:  Zenglin Pei; Xuan Zhang; Chunxia Ji; Song-Mei Liu; Jin Wang
Journal:  Oncotarget       Date:  2016-09-27
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  15 in total

Review 1.  Signaling and Regulation of the Mitochondrial Unfolded Protein Response.

Authors:  Nandhitha Uma Naresh; Cole M Haynes
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-06-03       Impact factor: 10.005

2.  Expression patterns of activating transcription factor 5 (atf5a and atf5b) in zebrafish.

Authors:  Roberto Rodríguez-Morales; Viveca Vélez-Negrón; Aranza Torrado-Tapias; Gaurav Varshney; Martine Behra
Journal:  Gene Expr Patterns       Date:  2020-07-11       Impact factor: 1.224

Review 3.  The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.

Authors:  Tomer Shpilka; Cole M Haynes
Journal:  Nat Rev Mol Cell Biol       Date:  2017-11-22       Impact factor: 94.444

Review 4.  Role of the mitochondrial stress response in human cancer progression.

Authors:  Sheng-Fan Wang; Shiuan Chen; Ling-Ming Tseng; Hsin-Chen Lee
Journal:  Exp Biol Med (Maywood)       Date:  2020-04-23

Review 5.  Mitochondrial Stress Response and Cancer.

Authors:  Jordan O'Malley; Rahul Kumar; Joseph Inigo; Nagendra Yadava; Dhyan Chandra
Journal:  Trends Cancer       Date:  2020-05-22

6.  Dominant-Negative ATF5 Compromises Cancer Cell Survival by Targeting CEBPB and CEBPD.

Authors:  Xiaotian Sun; Parvaneh Jefferson; Qing Zhou; James M Angelastro; Lloyd A Greene
Journal:  Mol Cancer Res       Date:  2019-11-01       Impact factor: 5.852

7.  ATF5 and HIF1α cooperatively activate HIF1 signaling pathway in esophageal cancer.

Authors:  Feng He; Hang Xiao; Yixin Cai; Ni Zhang
Journal:  Cell Commun Signal       Date:  2021-05-12       Impact factor: 5.712

Review 8.  The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer.

Authors:  Thomas K Sears; James M Angelastro
Journal:  Oncotarget       Date:  2017-09-20

9.  Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells.

Authors:  Junjie Wang; Dongdong Fu; Soulixay Senouthai; Yan Jiang; Rentong Hu; Yanwu You
Journal:  Mediators Inflamm       Date:  2019-04-15       Impact factor: 4.711

10.  Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents.

Authors:  Qing Zhou; Xiotian Sun; Nicolas Pasquier; Parvaneh Jefferson; Trang T T Nguyen; Markus D Siegelin; James M Angelastro; Lloyd A Greene
Journal:  Cancers (Basel)       Date:  2021-05-20       Impact factor: 6.639
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