| Literature DB >> 2871787 |
P S Auerbach, J Osterloh, O Braun, P Hu, E C Geehr, K W Kizer, H McKinney.
Abstract
A prospective study was done to compare the efficacy of gastric emptying achieved by gastric lavage (GL) with that of ipecac-induced emesis (IE) in victims of drug overdose. Thiamine was used as a marker of recovery in gastric samples, as measured by ion exchange/ion pair high-performance liquid chromatography. There were 51 patients in the IE group and 37 in the GL group. GL produced a higher mean per cent recovery of thiamine than did IE (90% +/- 34% compared with 50% +/- 35%). There was a significant difference between the two groups (P less than .001). Recovery of thiamine was more than 70% in 28% of the IE patients, and exceeded 70% in 75% of GL patients. When gastric emptying is desired for management of the adult overdose victim, the use of GL maximizes the chance of recovering unabsorbed liquid drugs from the stomach.Entities:
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Year: 1986 PMID： 2871787 DOI： 10.1016/s0196-0644(86)80427-9
Source DB: PubMed Journal: Ann Emerg Med ISSN： 0196-0644 Impact factor: 5.721