Literature DB >> 28716888

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer.

Juming Yan1,2, Mark J Smyth2,3, Michele W L Teng1,2.   

Abstract

The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy.
Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2018        PMID： 28716888      PMCID： PMC6028064          DOI： 10.1101/cshperspect.a028530

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  148 in total

1.  Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy.

Authors:  Irma Airoldi; Emma Di Carlo; Claudia Cocco; Carlo Sorrentino; Franco Fais; Michele Cilli; Tommaso D'Antuono; Mario Paolo Colombo; Mario Paulo Colombo; Vito Pistoia
Journal:  Blood       Date:  2005-08-04       Impact factor: 22.113

2.  IL-17, IL-23, and p73 expression in cutaneous melanoma: a pilot study.

Authors:  Giulia Ganzetti; Corrado Rubini; Anna Campanati; Antonio Zizzi; Elisa Molinelli; Laura Rosa; Francesco Simonacci; Annamaria Offidani
Journal:  Melanoma Res       Date:  2015-06       Impact factor: 3.599

3.  IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis.

Authors:  Michele W L Teng; Daniel M Andrews; Nicole McLaughlin; Bianca von Scheidt; Shin Foong Ngiow; Andreas Möller; Geoffrey R Hill; Yoichiro Iwakura; Martin Oft; Mark J Smyth
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

4.  Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.

Authors:  JiHoon Chang; Timothy J Voorhees; Yusen Liu; Yongge Zhao; Cheong-Hee Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

5.  Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor.

Authors:  Jun Li; Le Zhang; Jie Zhang; Yuyan Wei; Kai Li; Lugang Huang; Sen Zhang; Bo Gao; Xiujie Wang; Ping Lin
Journal:  Carcinogenesis       Date:  2012-12-17       Impact factor: 4.944

6.  Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma.

Authors:  Peng Hu; Huai-Dong Hu; Min Chen; Ming-Li Peng; Li Tang; Kai-Fu Tang; Masanori Matsui; Maria Laura Belladonna; Takayuki Yoshimoto; Da-Zhi Zhang; Rong Xiang; Hong Ren
Journal:  Mol Immunol       Date:  2009-03-18       Impact factor: 4.407

7.  IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.

Authors:  Emmanuella Guenova; Yuliya Skabytska; Wolfram Hoetzenecker; Günther Weindl; Karin Sauer; Manuela Tham; Kyu-Won Kim; Ji-Hyeon Park; Ji Hae Seo; Desislava Ignatova; Antonio Cozzio; Mitchell P Levesque; Thomas Volz; Martin Köberle; Susanne Kaesler; Peter Thomas; Reinhard Mailhammer; Kamran Ghoreschi; Knut Schäkel; Boyko Amarov; Martin Eichner; Martin Schaller; Rachael A Clark; Martin Röcken; Tilo Biedermann
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-02       Impact factor: 11.205

Review 8.  Therapeutic opportunities of the IL-22-IL-22R1 system.

Authors:  Robert Sabat; Wenjun Ouyang; Kerstin Wolk
Journal:  Nat Rev Drug Discov       Date:  2014-01       Impact factor: 84.694

Review 9.  Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.

Authors:  Robert D Schreiber; Lloyd J Old; Mark J Smyth
Journal:  Science       Date:  2011-03-25       Impact factor: 47.728

10.  Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells.

Authors:  Franca Gerosa; Barbara Baldani-Guerra; Lyudmila A Lyakh; Giovanna Batoni; Semih Esin; Robin T Winkler-Pickett; Maria Rita Consolaro; Mario De Marchi; Daniela Giachino; Angela Robbiano; Marco Astegiano; Angela Sambataro; Robert A Kastelein; Giuseppe Carra; Giorgio Trinchieri
Journal:  J Exp Med       Date:  2008-05-19       Impact factor: 14.307
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  41 in total

Review 1.  Interleukin-6 Family Cytokines.

Authors:  Stefan Rose-John
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-02-01       Impact factor: 10.005

2.  Anti-IL-23 exerted protective effects on cerebral ischemia-reperfusion injury through JAK2/STAT3 signaling pathway.

Authors:  Lichao Fan; Lichun Zhou
Journal:  Mol Biol Rep       Date:  2021-04-26       Impact factor: 2.316

Review 3.  The Immunobiology of the Interleukin-12 Family: Room for Discovery.

Authors:  Elia D Tait Wojno; Christopher A Hunter; Jason S Stumhofer
Journal:  Immunity       Date:  2019-04-16       Impact factor: 31.745

Review 4.  Th17 cells and their related cytokines: vital players in progression of malignant pleural effusion.

Authors:  Yiran Niu; Qiong Zhou
Journal:  Cell Mol Life Sci       Date:  2022-03-17       Impact factor: 9.261

5.  Surgery for Obesity and Weight-Related Diseases Changes the Inflammatory Profile in Women with Severe Obesity: a Randomized Controlled Clinical Trial.

Authors:  Alan Robson Trigueiro de Sousa; Wilson Rodrigues Freitas Junior; Eduardo Araujo Perez; Elias Jirjoss Ilias; Anderson Soares Silva; Vera Lucia Santos Alves; João Pedro Ribeiro Afonso; Miriã Cândida Oliveira; Adriano Luís Fonseca; Marcos Mota da Silva; Maria Eduarda Moreira Lino; Manoel Carneiro Oliveira Junior; Rodolfo Paula Vieira; Wilson José Sena Pedro; André Luis Lacerda Bachi; Giuseppe Insalaco; Carlos Alberto Malheiros; Luis Vicente Franco Oliveira
Journal:  Obes Surg       Date:  2021-09-23       Impact factor: 4.129

6.  Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.

Authors:  Danze Chen; Shijia Hao; Jianzhen Xu
Journal:  Front Cell Dev Biol       Date:  2021-03-11

7.  Skin Inflammation Modulation via TNF-α, IL-17, and IL-12 Family Inhibitors Therapy and Cancer Control in Patients with Psoriasis.

Authors:  Daniel Octavian Costache; Oana Feroiu; Adelina Ghilencea; Mihaela Georgescu; Ana Căruntu; Constantin Căruntu; Sorin George Țiplica; Mariana Jinga; Raluca Simona Costache
Journal:  Int J Mol Sci       Date:  2022-05-06       Impact factor: 6.208

Review 8.  Interleukins in cancer: from biology to therapy.

Authors:  Daria Briukhovetska; Janina Dörr; Stefan Endres; Peter Libby; Charles A Dinarello; Sebastian Kobold
Journal:  Nat Rev Cancer       Date:  2021-06-03       Impact factor: 69.800

9.  Evaluation of cytokines in the tumor microenvironment of lung cancer using bronchoalveolar lavage fluid analysis.

Authors:  Pascal Bezel; Alan Valaperti; Urs Steiner; Dieter Scholtze; Stephan Wieser; Maya Vonow-Eisenring; Andrea Widmer; Benedikt Kowalski; Malcolm Kohler; Daniel P Franzen
Journal:  Cancer Immunol Immunother       Date:  2021-01-04       Impact factor: 6.968

10.  Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Authors:  Christopher S Garris; Sean P Arlauckas; Rainer H Kohler; Marcel P Trefny; Seth Garren; Cécile Piot; Camilla Engblom; Christina Pfirschke; Marie Siwicki; Jeremy Gungabeesoon; Gordon J Freeman; Sarah E Warren; SuFey Ong; Erica Browning; Christopher G Twitty; Robert H Pierce; Mai H Le; Alain P Algazi; Adil I Daud; Sara I Pai; Alfred Zippelius; Ralph Weissleder; Mikael J Pittet
Journal:  Immunity       Date:  2018-12-11       Impact factor: 43.474
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