BACKGROUND: The impact of specific allergic rhinitis symptoms on patient quality of life (QOL) is currently unknown. OBJECTIVE: In this study, we sought to determine the association between nasal and extranasal symptoms of allergic rhinitis with general health-related QOL. METHODS: A total of 150 participants with ages > 18 years and persistent allergic rhinitis were prospectively recruited for this cross-sectional study. General health-related QOL was measured by using the visual analog scale (VAS) from the five-dimension EuroQol QOL survey (EQ-5D). The severity of nasal and extranasal symptoms was measured by using the 22-item Sino-Nasal Outcome Test (SNOT-22). The severity of nasal obstruction was measured by using the Nasal Obstruction Severity Evaluation (NOSE) scale. Each participant also completed a Rhinitis Control Assessment Test (RCAT). RESULTS: The total SNOT-22 score was significantly correlated with RCAT (r = -0.68 [95% confidence interval {CI}, -0.75 to -0.58]; p < 0.001) and EQ-5D VAS (r = -0.44 [95% CI, -0.56 to -0.30]; p < 0.001). Of the 22 symptoms assessed on the SNOT-22, sleep-related symptoms, and otologic symptoms were associated with the greatest decrease in general health-related QOL. Nasal symptoms were least associated with general health-related QOL. The symptom of nasal obstruction was not at all associated with general health-related QOL (p = 0.267). We confirmed this finding by showing no significant correlation between the NOSE score and EQ-5D VAS (r = -0.05 [95% CI, -0.21 to 0.12]; p = 0.582). CONCLUSION: Sleep and otologic symptoms were associated with the greatest negative impact on QOL in adults with persistent allergic rhinitis and should be routinely assessed in their clinical evaluation.
BACKGROUND: The impact of specific allergic rhinitis symptoms on patient quality of life (QOL) is currently unknown. OBJECTIVE: In this study, we sought to determine the association between nasal and extranasal symptoms of allergic rhinitis with general health-related QOL. METHODS: A total of 150 participants with ages > 18 years and persistent allergic rhinitis were prospectively recruited for this cross-sectional study. General health-related QOL was measured by using the visual analog scale (VAS) from the five-dimension EuroQol QOL survey (EQ-5D). The severity of nasal and extranasal symptoms was measured by using the 22-item Sino-Nasal Outcome Test (SNOT-22). The severity of nasal obstruction was measured by using the Nasal Obstruction Severity Evaluation (NOSE) scale. Each participant also completed a Rhinitis Control Assessment Test (RCAT). RESULTS: The total SNOT-22 score was significantly correlated with RCAT (r = -0.68 [95% confidence interval {CI}, -0.75 to -0.58]; p < 0.001) and EQ-5D VAS (r = -0.44 [95% CI, -0.56 to -0.30]; p < 0.001). Of the 22 symptoms assessed on the SNOT-22, sleep-related symptoms, and otologic symptoms were associated with the greatest decrease in general health-related QOL. Nasal symptoms were least associated with general health-related QOL. The symptom of nasal obstruction was not at all associated with general health-related QOL (p = 0.267). We confirmed this finding by showing no significant correlation between the NOSE score and EQ-5D VAS (r = -0.05 [95% CI, -0.21 to 0.12]; p = 0.582). CONCLUSION: Sleep and otologic symptoms were associated with the greatest negative impact on QOL in adults with persistent allergic rhinitis and should be routinely assessed in their clinical evaluation.
Authors: Marlene M Speth; Katie M Phillips; Lloyd P Hoehle; David S Caradonna; Stacey T Gray; Ahmad R Sedaghat Journal: Eur Arch Otorhinolaryngol Date: 2019-07-19 Impact factor: 2.503
Authors: David T Liu; Katie M Phillips; Firas A Houssein; Marlene M Speth; Gerold Besser; Christian A Mueller; Ahmad R Sedaghat Journal: Laryngoscope Date: 2022-03-30 Impact factor: 2.970
Authors: Olga Lourenço; Biljana Cvetkovski; Vicky Kritikos; Rachel House; Sophie Scheire; Elisio M Costa; João A Fonseca; Enrica Menditto; Anna Bedbrook; Slawomir Bialek; Vitalis Briedis; Koen Boussery; G Walter Canonica; Tari Haahtela; Piotr Kuna; Joaquim Mullol; Valentina Orlando; Boleslaw Samolinski; Dana Wallace; Catherine Duggan; Ema Paulino; Gonçalo S Pinto; Lars-Åke Söderlund; Jean Bousquet; Sinthia Bosnic-Anticevich Journal: Clin Transl Allergy Date: 2022-10-05 Impact factor: 5.657