Königbauer Josephine1, Letsch Josefine1, Doebler Philipp2, Ebert David3, Baumeister Harald4. 1. University of Ulm, Institute of Psychology and Education, Department of Clinical Psychology and Psychotherapy, Germany. 2. TU Dortmund University, Faculty of Statistics, Chair of Statistical Methods in Social Sciences, Germany. 3. Friedrich-Alexander University of Erlangen-Nürnberg, Clinical Psychology and Psychotherapy, Germany. 4. University of Ulm, Institute of Psychology and Education, Department of Clinical Psychology and Psychotherapy, Germany. Electronic address: harald.baumeister@uni-ulm.de.
Abstract
BACKGROUND: To summarize and critically evaluate the effectiveness of internet- and mobile-based interventions (IMIs) for depression in adults with a diagnosed depression. METHODS: Preregistered systematic review of RCTs investigating internet- and mobile-based interventions (IMIs) targeting adults with diagnosed depression. IMIs had to be compared with waitlist, attention placebo, other IMIs or other (face-to-face) therapies. A comprehensive search of primary studies was conducted. Study selection and data extraction was done by two independent researchers. Primary outcome was symptom severity of depression. Furthermore, treatment response, depression remission, treatment adherence, anxiety and quality of life were investigated. Random-effects meta-analyses were conducted where possible, as well as pre-planned subgroup and sensitivity analyses. RESULTS: Database search resulted in 4858 references, of which 19 studies were eligible for inclusion and provided data on 29 IMIs. IMIs showed beneficial effects on depression severity when compared to waitlist conditions at the end of treatment (pooled standardized mean difference (SMD) g = -0.90, 95% CI -1.07 to -0.73, n = 10). The comparison between different IMIs did not result in any superiority or inferiority. All IMIs reduced depression symptoms from pre- to post-treatment (within group SMD range -2.24; -0.64, n = 29) and from pre-treatment to follow-up assessments (SMD range -3.07; -0.93, n = 27). CONCLUSION: IMIs significantly reduce depression symptoms in adults with diagnosed depression at the end of treatment and at follow-up assessments when compared to waitlist conditions. These findings argue for IMIs to be recommended in depression treatment guidelines.
BACKGROUND: To summarize and critically evaluate the effectiveness of internet- and mobile-based interventions (IMIs) for depression in adults with a diagnosed depression. METHODS: Preregistered systematic review of RCTs investigating internet- and mobile-based interventions (IMIs) targeting adults with diagnosed depression. IMIs had to be compared with waitlist, attention placebo, other IMIs or other (face-to-face) therapies. A comprehensive search of primary studies was conducted. Study selection and data extraction was done by two independent researchers. Primary outcome was symptom severity of depression. Furthermore, treatment response, depression remission, treatment adherence, anxiety and quality of life were investigated. Random-effects meta-analyses were conducted where possible, as well as pre-planned subgroup and sensitivity analyses. RESULTS: Database search resulted in 4858 references, of which 19 studies were eligible for inclusion and provided data on 29 IMIs. IMIs showed beneficial effects on depression severity when compared to waitlist conditions at the end of treatment (pooled standardized mean difference (SMD) g = -0.90, 95% CI -1.07 to -0.73, n = 10). The comparison between different IMIs did not result in any superiority or inferiority. All IMIs reduced depression symptoms from pre- to post-treatment (within group SMD range -2.24; -0.64, n = 29) and from pre-treatment to follow-up assessments (SMD range -3.07; -0.93, n = 27). CONCLUSION: IMIs significantly reduce depression symptoms in adults with diagnosed depression at the end of treatment and at follow-up assessments when compared to waitlist conditions. These findings argue for IMIs to be recommended in depression treatment guidelines.
Authors: Randy P Auerbach; Philippe Mortier; Ronny Bruffaerts; Jordi Alonso; Corina Benjet; Pim Cuijpers; Koen Demyttenaere; David D Ebert; Jennifer Greif Green; Penelope Hasking; Elaine Murray; Matthew K Nock; Stephanie Pinder-Amaker; Nancy A Sampson; Dan J Stein; Gemma Vilagut; Alan M Zaslavsky; Ronald C Kessler Journal: J Abnorm Psychol Date: 2018-09-13
Authors: Mathias Harrer; Sophia H Adam; Harald Baumeister; Pim Cuijpers; Eirini Karyotaki; Randy P Auerbach; Ronald C Kessler; Ronny Bruffaerts; Matthias Berking; David D Ebert Journal: Int J Methods Psychiatr Res Date: 2018-12-26 Impact factor: 4.035
Authors: J P Klein; C Knaevelsrud; M Bohus; D D Ebert; G Gerlinger; K Günther; C Jacobi; M Löbner; S G Riedel-Heller; J Sander; U Sprick; I Hauth Journal: Nervenarzt Date: 2018-11 Impact factor: 1.214
Authors: R Meister; A Jansen; M Berger; H Baumeister; T Bschor; T Harfst; M Hautzinger; L Kriston; C Kühner; H Schauenburg; S G Schorr; F Schneider; M Härter Journal: Nervenarzt Date: 2018-03 Impact factor: 1.214
Authors: Philippe Mortier; Randy P Auerbach; Jordi Alonso; Jason Bantjes; Corina Benjet; Pim Cuijpers; David D Ebert; Jennifer Greif Green; Penelope Hasking; Matthew K Nock; Siobhan O'Neill; Stephanie Pinder-Amaker; Nancy A Sampson; Gemma Vilagut; Alan M Zaslavsky; Ronny Bruffaerts; Ronald C Kessler Journal: J Am Acad Child Adolesc Psychiatry Date: 2018-02-13 Impact factor: 8.829