| Literature DB >> 28715642 |
Emily A K Prieur1, Eneda Pjetri2,3,4, Steven H Zeisel2,3,4, Nafisa M Jadavji1,5.
Abstract
Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.Entities:
Keywords: IRM; MRI; Morris water maze; Y-maze; betaine homocysteine S-methyltransferase; bétaïne homocystéine S-méthyltransférase; homocysteine; homocystéine; labyrinthe aquatique de Morris; labyrinthe en Y; memory; mémoire
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Year: 2017 PMID： 28715642 DOI： 10.1139/apnm-2017-0182
Source DB: PubMed Journal: Appl Physiol Nutr Metab ISSN： 1715-5312 Impact factor: 2.665