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Literature DB >> 28714998

Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions.

Mette Ishoey¹, Rico G Petersen, Michael Å Petersen, Peng Wu, Mads H Clausen, Thomas E Nielsen.

Abstract

A high-yielding, stereoselective and extraordinarily complexity-generating Petasis 3-component/intramolecular Diels-Alder reaction has been developed. In combination with ROM-RCM, rapid access to complex sp3-rich heterocyclic scaffolds amenable to subsequent functionalization and library synthesis is provided.

Year: 2017 PMID： 28714998 DOI： 10.1039/c7cc02948a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

2 in total

1. Build-Couple-Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity.

Authors: Mélanie Uguen; Gemma Davison; Lukas J Sprenger; James H Hunter; Mathew P Martin; Shannon Turberville; Jessica E Watt; Bernard T Golding; Martin E M Noble; Hannah L Stewart; Michael J Waring
Journal: J Med Chem Date: 2022-08-09 Impact factor: 8.039

2. Reactivity and Synthetic Applications of Multicomponent Petasis Reactions.

Authors: Peng Wu; Michael Givskov; Thomas E Nielsen
Journal: Chem Rev Date: 2019-08-27 Impact factor: 60.622

2 in total