Rie Kuge1, Yoshihiko Morikawa2, Yukihiro Hasegawa3. 1. Support Center for Children and Family, Department of Psychology and Welfare, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 2. Clinical Research Support Center, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan. 3. Department of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Abstract
BACKGROUND: Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment. The gold standard for assessment is acute weight loss. Dehydration severity, as determined by weight loss, significantly correlates with serum urea nitrogen (UN) in children with AGE. The disadvantage of using serum UN as a marker of dehydration severity, however, is that the level can be affected by nutrition. Serum uric acid (UA) theoretically could serve as an alternative in this regard, but there have been no reports on the direct relationship between serum UA and weight loss. The aim of this study was therefore to assess the relationship between serum UA and weight loss in patients with AGE. METHODS: This was a prospective observational study of children 1-71 months of age admitted to Tokyo Metropolitan Children's Medical Center with AGE between 1 December 2010 and 31 March 2015. Patients with symptoms of AGE ≥ 8 days, chronic disease, or incomplete data were excluded from the study. Pre-post-rehydration weight change was used as an alternative, gold standard marker for the assessment of dehydration severity. RESULTS: The study participants consisted of 97 children. Serum UA correlated significantly with weight change, and increased significantly along with dehydration severity. CONCLUSIONS: Serum UA can be considered as an adjunct to the clinical assessment of dehydration in children with AGE.
BACKGROUND: Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is crucial for treatment. The gold standard for assessment is acute weight loss. Dehydration severity, as determined by weight loss, significantly correlates with serum ureanitrogen (UN) in children with AGE. The disadvantage of using serum UN as a marker of dehydration severity, however, is that the level can be affected by nutrition. Serum uric acid (UA) theoretically could serve as an alternative in this regard, but there have been no reports on the direct relationship between serum UA and weight loss. The aim of this study was therefore to assess the relationship between serum UA and weight loss in patients with AGE. METHODS: This was a prospective observational study of children 1-71 months of age admitted to Tokyo Metropolitan Children's Medical Center with AGE between 1 December 2010 and 31 March 2015. Patients with symptoms of AGE ≥ 8 days, chronic disease, or incomplete data were excluded from the study. Pre-post-rehydration weight change was used as an alternative, gold standard marker for the assessment of dehydration severity. RESULTS: The study participants consisted of 97 children. Serum UA correlated significantly with weight change, and increased significantly along with dehydration severity. CONCLUSIONS: Serum UA can be considered as an adjunct to the clinical assessment of dehydration in children with AGE.