H Minebois1, A De Souza2, C Mezan de Malartic3, M Agopiantz4, F Guillet May5, O Morel6, R Callec7. 1. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: helene2104@aol.com. 2. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: anaisdesouz@gmail.com. 3. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: C.mezandemalartic@chru-nancy.fr. 4. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: m.agopiantz@chru-nancy.fr. 5. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: F.guillet-may@chru-nancy.fr. 6. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: olivier.morel17@gmail.com. 7. Maternité régionale universitaire, centre hospitalier universitaire de Nancy, rue Heydenreich, 54000 Nancy, France. Electronic address: ronancallec@yahoo.fr.
Abstract
OBJECTIVES: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriage. The aim of this study is to evaluate the association between endometriosis and miscarriage in spontaneous pregnancy. METHODS: We searched the Cochrane Library, Medline of eligible studies from inception to December 2016, without any restriction. We selected studies that compared endometriosis-affected pregnant women to disease-free pregnant women. To ensure the quality of the methodology, the PRISMA criteria have been met at all stages of the development of this meta-analysis. The primary adverse pregnancy outcomes studied was miscarriage. Three reviewers independently extracted the studies' characteristics and outcome data. RESULTS: Of 225 identified abstracts, 4 primary studies met our inclusion criteria by comparing spontaneous pregnant patients with endometriosis to disease-free women. Miscarriage rate was higher in the endometriosis group (OR 1.77 [CI 95% 1.13-2.78]). CONCLUSION: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriages (almost 80% increased risk). Further prospective studies are needed to confirm these results in order to establish the exact impact of endometriosis on spontaneous pregnancy course.
OBJECTIVES: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriage. The aim of this study is to evaluate the association between endometriosis and miscarriage in spontaneous pregnancy. METHODS: We searched the Cochrane Library, Medline of eligible studies from inception to December 2016, without any restriction. We selected studies that compared endometriosis-affected pregnant women to disease-free pregnant women. To ensure the quality of the methodology, the PRISMA criteria have been met at all stages of the development of this meta-analysis. The primary adverse pregnancy outcomes studied was miscarriage. Three reviewers independently extracted the studies' characteristics and outcome data. RESULTS: Of 225 identified abstracts, 4 primary studies met our inclusion criteria by comparing spontaneous pregnant patients with endometriosis to disease-free women. Miscarriage rate was higher in the endometriosis group (OR 1.77 [CI 95% 1.13-2.78]). CONCLUSION: In spontaneous pregnancies, endometriosis appears to be a risk factor of miscarriages (almost 80% increased risk). Further prospective studies are needed to confirm these results in order to establish the exact impact of endometriosis on spontaneous pregnancy course.
Authors: Michael P Rimmer; Ruth A Howie; Venkatesh Subramanian; Richard A Anderson; Ricardo Pimenta Bertolla; Yusuf Beebeejaun; Pietro Bortoletto; Sesh K Sunkara; Rod T Mitchell; Allan Pacey; Madelon van Wely; Cindy M Farquhar; James M N Duffy; Craig Niederberger Journal: Hum Reprod Open Date: 2022-03-04