Marcello Esposito1, Raffaele Dubbioso1, Silvio Peluso1, Antonio Picone2, Bruno Corrado2, Clemente Servodio Iammarone2, Roberto Allocca1, Fiore Manganelli1, Lucio Santoro1, Alfonso Fasano3. 1. Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Italy. 2. Orthopedic Surgery Department, Rehabilitation Unit, Federico II University, Naples, Italy. 3. Morton and Gloria Shulman Movement Disorders Centre, The Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, Toronto, Ontario, Canada. Electronic address: alfonso.fasano@gmail.com.
Abstract
INTRODUCTION: Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities. OBJECTIVE: to assess walking motor pattern in CD patients without DBS and not presenting scoliosis. METHODS: Computerized gait analysis (CGA) was performed in CD patients, before and after botulinum toxin (BoNT) injections, and in healthy controls (HC). Spatiotemporal (ST) parameters were compared between CD and HC groups. Correlation analysis was conducted between ST parameters and clinical features of CD patients. RESULTS: CD patients demonstrated a significant reduction of velocity, stride length, % of swing phase, and dynamic stability index while stride and swing time were increased. No significant effect of BoNT was detected. A significant inverse correlation was found between TWSTRS and stride length. CONCLUSION: CD patients may have a slow gait with subclinical evidence. Our data suggest this alteration might be an endophenotipic feature of CD.
INTRODUCTION: Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities. OBJECTIVE: to assess walking motor pattern in CDpatients without DBS and not presenting scoliosis. METHODS: Computerized gait analysis (CGA) was performed in CDpatients, before and after botulinum toxin (BoNT) injections, and in healthy controls (HC). Spatiotemporal (ST) parameters were compared between CD and HC groups. Correlation analysis was conducted between ST parameters and clinical features of CDpatients. RESULTS:CDpatients demonstrated a significant reduction of velocity, stride length, % of swing phase, and dynamic stability index while stride and swing time were increased. No significant effect of BoNT was detected. A significant inverse correlation was found between TWSTRS and stride length. CONCLUSION:CDpatients may have a slow gait with subclinical evidence. Our data suggest this alteration might be an endophenotipic feature of CD.
Authors: M J Boyce; A B McCambridge; L V Bradnam; C G Canning; N Mahant; F C F Chang; V S C Fung; A P Verhagen Journal: J Neural Transm (Vienna) Date: 2021-07-31 Impact factor: 3.575