Eric P Slade1, Jennifer D Gottlieb1, Weili Lu1, Philip T Yanos1, Stanley Rosenberg1, Steven M Silverstein1, Shula K Minsky1, Kim T Mueser1. 1. Dr. Slade is with the Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, and the U.S. Department of Veterans Affairs (VA) Capitol Health Care Network (Veterans Integrated Service Network 5) Mental Illness Research, Education, and Clinical Center. Dr. Gottlieb and Dr. Mueser are with the Center for Psychiatric Rehabilitation, Boston University, Boston. Dr. Lu is with the Department of Psychiatric Rehabilitation and Counseling Professions, Rutgers University School of Health Professions, Newark, New Jersey. Dr. Yanos is with the Department of Psychology, John Jay College of Criminal Justice, City University of New York, New York. Dr. Rosenberg is with the Department of Psychiatry, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire. Dr. Silverstein is with the Division of Schizophrenia Research and Dr. Minsky is with the Department of Quality Improvement and the Department of Psychiatry, Rutgers University Behavioral Health Care, Piscataway, New Jersey.
Abstract
OBJECTIVE: This study examined the cost-effectiveness of a cognitive-behavioral therapy (CBT) intervention for posttraumatic stress disorder (PTSD) that is tailored for adults with a co-occurring severe mental illness. METHODS: Data were from a randomized trial involving 183 adult clients of two outpatient clinics and three partial hospitalization programs. All had a severe mental illness diagnosis (major mood disorder, schizophrenia, or schizoaffective disorder) and severe PTSD. Participants were randomly assigned to the tailored 12- to 16-session CBT intervention for PTSD (CBT-P) or a three-session breathing retraining and psychoeducation intervention (BRF). Cost estimates included intervention costs for training, supervision, fidelity assessment, personnel, and overhead and related mental health care costs for outpatient, inpatient, and emergency department services and for medications. The incremental cost-effectiveness ratio comparing CBT-P with BRF measured the added cost or savings per remission from PTSD at 12 months postintervention. Generalized linear models were used to estimate intervention effects on annual mental health care costs and the likelihood of a remission from PTSD. Ten thousand bootstrap replications were used to assess uncertainty. RESULTS:Annual mean mental health care costs were $25,539 per client (in 2010 dollars) for BRF participants and $29,530 per client for CBT-P participants, a nonsignificant difference. The mean incremental cost-effectiveness ratio was $36,893 per additional PTSD remission yielded by CBT-P compared with BRF (95% confidence interval=-$33,523 to $158,914). Remissions were associated with improvements in quality of life and functioning. CONCLUSIONS: An effective CBT intervention tailored for adults with severe mental illness and PTSD was not found to be more cost-effective than a brief three-session intervention.
RCT Entities:
OBJECTIVE: This study examined the cost-effectiveness of a cognitive-behavioral therapy (CBT) intervention for posttraumatic stress disorder (PTSD) that is tailored for adults with a co-occurring severe mental illness. METHODS: Data were from a randomized trial involving 183 adult clients of two outpatient clinics and three partial hospitalization programs. All had a severe mental illness diagnosis (major mood disorder, schizophrenia, or schizoaffective disorder) and severe PTSD. Participants were randomly assigned to the tailored 12- to 16-session CBT intervention for PTSD (CBT-P) or a three-session breathing retraining and psychoeducation intervention (BRF). Cost estimates included intervention costs for training, supervision, fidelity assessment, personnel, and overhead and related mental health care costs for outpatient, inpatient, and emergency department services and for medications. The incremental cost-effectiveness ratio comparing CBT-P with BRF measured the added cost or savings per remission from PTSD at 12 months postintervention. Generalized linear models were used to estimate intervention effects on annual mental health care costs and the likelihood of a remission from PTSD. Ten thousand bootstrap replications were used to assess uncertainty. RESULTS: Annual mean mental health care costs were $25,539 per client (in 2010 dollars) for BRFparticipants and $29,530 per client for CBT-Pparticipants, a nonsignificant difference. The mean incremental cost-effectiveness ratio was $36,893 per additional PTSD remission yielded by CBT-P compared with BRF (95% confidence interval=-$33,523 to $158,914). Remissions were associated with improvements in quality of life and functioning. CONCLUSIONS: An effective CBT intervention tailored for adults with severe mental illness and PTSD was not found to be more cost-effective than a brief three-session intervention.
Authors: Kim T Mueser; Stanley D Rosenberg; Haiyi Xie; M Kay Jankowski; Elisa E Bolton; Weili Lu; Jessica L Hamblen; Harriet J Rosenberg; Gregory J McHugo; Rosemarie Wolfe Journal: J Consult Clin Psychol Date: 2008-04
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: K T Mueser; L B Goodman; S L Trumbetta; S D Rosenberg; f C Osher; R Vidaver; P Auciello; D W Foy Journal: J Consult Clin Psychol Date: 1998-06
Authors: Weili Lu; Philip T Yanos; Jennifer D Gottlieb; Stephanie Marcello Duva; Steven M Silverstein; Haiyi Xie; Stanley D Rosenberg; Kim T Mueser Journal: Psychiatr Serv Date: 2012-08 Impact factor: 3.084
Authors: Anke Ehlers; Jennifer Wild; Emma Warnock-Parkes; Nick Grey; Hannah Murray; Alice Kerr; Alexander Rozental; Esther T Beierl; Apostolos Tsiachristas; Rafael Perera-Salazar; Gerhard Andersson; David M Clark Journal: Trials Date: 2020-04-23 Impact factor: 2.279