Shireen Jawed1, Nighat Mannan2, Masood Anwar Qureshi3. 1. Department, Physiology, University Medical and Dental College Faisalabad, University of Faisalabad, Pakistan. 2. Bahria University Medical and Dental College, Karachi, Pakistan. 3. Institute of Basic Medical Sciences, Dow University of Health Sciences, Karachi, Pakistan.
Abstract
BACKGROUND: Obesity is associated with inflammatory diseases and obese individual's poses high risk for infections. Surfactant protein D (SP-D) is an important regulator of immunity and inflammation. Latest studies have suggested that it is also involved in lipid homeostasis and obese subjects have decrease concentration of SP-D as compared to normal weight peoples. The aim of the current study was to elucidate the relationship among serum SP-D and BMI. METHODS: This cross sectional study was performed at Dow University of health sciences (DUHS), Karachi. We analysed 90 obese and non-obese subjects for serum SP-D concentration. SP-D was estimated by ELISA. Data was analysed by SPSS 16. Mean SP-D level and demographical variables between the groups were compared by t test, Associations of SP-D with BMI investigated by regression analysis. RESULTS: obese subjects have significant lower levels of Serum SP-D than non-obese and negatively associated with BMI in both genders (p=0.000). CONCLUSIONS: This study concluded that obese subjects have lower concentration of SP-D as compare to non-obese and there is an inverse association between the SP-D and BMI.
BACKGROUND: Obesity is associated with inflammatory diseases and obese individual's poses high risk for infections. Surfactant protein D (SP-D) is an important regulator of immunity and inflammation. Latest studies have suggested that it is also involved in lipid homeostasis and obese subjects have decrease concentration of SP-D as compared to normal weight peoples. The aim of the current study was to elucidate the relationship among serum SP-D and BMI. METHODS: This cross sectional study was performed at Dow University of health sciences (DUHS), Karachi. We analysed 90 obese and non-obese subjects for serum SP-D concentration. SP-D was estimated by ELISA. Data was analysed by SPSS 16. Mean SP-D level and demographical variables between the groups were compared by t test, Associations of SP-D with BMI investigated by regression analysis. RESULTS:obese subjects have significant lower levels of Serum SP-D than non-obese and negatively associated with BMI in both genders (p=0.000). CONCLUSIONS: This study concluded that obese subjects have lower concentration of SP-D as compare to non-obese and there is an inverse association between the SP-D and BMI.
Entities:
Keywords:
Obesity; Surfactant Protein- D; Total Body Mass Index (BMI); inflammatory diseases
Authors: Shan L Ward; Mary K Dahmer; Heidi M Weeks; Anil Sapru; Michael W Quasney; Martha A Q Curley; Kathleen D Liu; Michael A Matthay; Heidi R Flori Journal: Pediatr Pulmonol Date: 2020-08-07
Authors: Elena V Kashtanova; Yana V Polonskaya; Evgeniia V Striukova; Liliia V Shcherbakova; Evgenii A Kurtukov; Viktoriya S Shramko; Ekaterina M Stakhneva; Yulia I Ragino Journal: Diagnostics (Basel) Date: 2022-01-25