Ozge Yabas Kiziloglu1, Mert Mestanoglu2, Ozgun Melike Totuk Gedar3, Cafer Adiguzel4, Okan Toygar3. 1. Department of Ophthalmology, Faculty of Medicine, Göztepe Medical Park Hospital, Bahcesehir University, E-5 uzeri 23 Nisan sok No: 17 Merdivenkoy, Kadikoy, Istanbul, Turkey. ozgeyabas@hotmail.com. 2. Faculty of Medicine, Bahcesehir University, Istanbul, Turkey. 3. Department of Ophthalmology, Faculty of Medicine, Göztepe Medical Park Hospital, Bahcesehir University, E-5 uzeri 23 Nisan sok No: 17 Merdivenkoy, Kadikoy, Istanbul, Turkey. 4. Department of Hematology, Faculty of Medicine, Bahcesehir University, E-5 uzeri 23 Nisan sok No: 17 Merdivenkoy, Kadikoy, Istanbul, Turkey.
Abstract
PURPOSE: The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling. METHODS: A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss. RESULTS: Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Magnetic resonance imaging for differential diagnosis was inconclusive; however, cerebrospinal fluid sampling demonstrated leukemic involvement of the central nervous system. The patient's vision improved and fundus findings resolved with the institution of systemic and intrathecal chemotherapy. CONCLUSIONS: Serous retinal detachment and optic disc swelling are unusual ocular manifestations of ALL. They may occur due to leukemic infiltration of ocular structures and may indicate extramedullary recurrence of the disease. Early recognition and treatment is crucial to improve prognosis.
PURPOSE: The aim of this case report is to describe a patient with acute lymphoblastic leukemia (ALL) who developed bilateral serous retinal detachments and unilateral optic disc swelling. METHODS: A 23-year-old woman with ALL presented to the ophthalmology clinic with bilateral subacute visual loss. RESULTS: Ophthalmologic examination revealed bilateral serous retinal detachments and unilateral optic disc swelling. Magnetic resonance imaging for differential diagnosis was inconclusive; however, cerebrospinal fluid sampling demonstrated leukemic involvement of the central nervous system. The patient's vision improved and fundus findings resolved with the institution of systemic and intrathecal chemotherapy. CONCLUSIONS:Serous retinal detachment and optic disc swelling are unusual ocular manifestations of ALL. They may occur due to leukemic infiltration of ocular structures and may indicate extramedullary recurrence of the disease. Early recognition and treatment is crucial to improve prognosis.