Muhammad Sarfraz Nawaz1, Kifayat Ullah Shah2, Tahir Mehmood Khan3, Asim Ur Rehman1, Haroon Ur Rashid1, Sajid Mahmood1, Shahzeb Khan4, Muhammad Junaid Farrukh4. 1. Department of Pharmacy, Quaid-i-Azam University Islamabad, Pakistan; Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia. 2. Department of Pharmacy, Quaid-i-Azam University Islamabad, Pakistan; Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia. Electronic address: kushah@qau.edu.pk. 3. School of Pharmacy, Monash University, Jalan Lagoon Selatan,47500 Bandar SunwaySelangor DarulEhsan, Malaysia. 4. Department of Pharmacy, University of Malakand, KPK, Pakistan; Faculty of Pharmaceutical Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia.
Abstract
OBJECTIVE: Diabetes mellitus is a major health problem in developing countries. There are various insulin therapies to manage diabetes mellitus. This systematic review evaluates various insulin therapies for management of diabetes mellitus worldwide. This review also focuses on recent developments being explored for better management of diabetes mellitus. RESEARCH DESIGN AND METHOD: We reviewed a number of published articles from 2002 to 2016 to find out the appropriate management of diabetes mellitus. The paramount parameters of the selected studies include the insulin type & its dose, type of diabetes, duration and comparison of different insulin protocols. In addition, various newly developed approaches for insulin delivery with potential output have also been evaluated. RESULTS: A great variability was observed in managing diabetes mellitus through insulin therapy and the important controlling factors found for this therapy include; dose titration, duration of insulin use, type of insulin used and combination therapy of different insulin. CONCLUSION: A range of research articles on current trends and recent advances in insulin has been summarized, which led us to the conclusion that multiple daily insulin injections or continuous subcutaneous insulin infusion (insulin pump) is the best method to manage diabetes mellitus. In future perspectives, development of the oral and inhalant insulin would be a tremendous breakthrough in Insulin therapy.
OBJECTIVE:Diabetes mellitus is a major health problem in developing countries. There are various insulin therapies to manage diabetes mellitus. This systematic review evaluates various insulin therapies for management of diabetes mellitus worldwide. This review also focuses on recent developments being explored for better management of diabetes mellitus. RESEARCH DESIGN AND METHOD: We reviewed a number of published articles from 2002 to 2016 to find out the appropriate management of diabetes mellitus. The paramount parameters of the selected studies include the insulin type & its dose, type of diabetes, duration and comparison of different insulin protocols. In addition, various newly developed approaches for insulin delivery with potential output have also been evaluated. RESULTS: A great variability was observed in managing diabetes mellitus through insulin therapy and the important controlling factors found for this therapy include; dose titration, duration of insulin use, type of insulin used and combination therapy of different insulin. CONCLUSION: A range of research articles on current trends and recent advances in insulin has been summarized, which led us to the conclusion that multiple daily insulin injections or continuous subcutaneous insulin infusion (insulin pump) is the best method to manage diabetes mellitus. In future perspectives, development of the oral and inhalant insulin would be a tremendous breakthrough in Insulin therapy.
Authors: Jie Li; Haiyan Shangguan; Xiaoqian Chen; Xiao Ye; Bin Zhong; Pen Chen; Yamei Wang; Bin Xin; Yan Bi; Dalong Zhu Journal: Open Life Sci Date: 2020-06-11 Impact factor: 0.938
Authors: Ha Young Yoon; Min Hye Lee; Yubin Song; Jeong Yee; Gonjin Song; Hye Sun Gwak Journal: Front Endocrinol (Lausanne) Date: 2021-04-23 Impact factor: 5.555