| Literature DB >> 28709776 |
Saki Hattori1, Ikuko Kishida2, Akira Suda3, Masatoshi Miyauchi4, Yohko Shiraishi5, Mami Fujibayashi6, Natsuki Tsujita7, Chie Ishii8, Norio Ishii9, Toshio Moritani10, Masataka Taguri11, Yoshio Hirayasu12.
Abstract
Antipsychotic drugs are associated with autonomic nervous system (ANS) dysfunction in patients with schizophrenia, but the effects of individual atypical antipsychotic drugs are not clear. This study investigated how four atypical antipsychotic drugs-risperidone, olanzapine, aripiprazole, and quetiapine-differ in their effects on ANS activity. A total of 241 Japanese patients with schizophrenia participated in this study. All of the participants received an atypical antipsychotic as monotherapy: 90 participants received risperidone, 68 olanzapine, 52 aripiprazole, and 31 quetiapine. ANS activity was assessed by means of a power spectral analysis of heart rate variability. The quetiapine group showed significantly diminished sympathetic and parasympathetic activity compared with the risperidone and aripiprazole groups and significantly lower sympathetic activity relative to olanzapine. In addition, multiple regression analysis showed that the type of antipsychotic drug significantly influenced ANS activity. We suggest that, among the antipsychotics examined-risperidone, olanzapine, aripiprazole and quetiapine-quetiapine has the strongest effect on ANS activity.Entities:
Keywords: Atypical antipsychotic drug; Autonomic nervous system; Heart rate variability; Schizophrenia
Mesh：
Substances：
Year: 2017 PMID： 28709776 DOI： 10.1016/j.schres.2017.07.004
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939