Literature DB >> 28707259

Rhabdomyolysis and AKI with Atorvastatin and Sitagliptin Use in the Setting of Low 25-Hydroxyvitamin D Levels.

Rupinder Singh Buttar1, Jasveen Batra1, Jacqueline Kreimerman1, Melissa Aleta1, Michal L Melamed2.   

Abstract

We report a case of an 86-year-old woman admitted to the hospital with rhabdomyolysis and acute kidney injury 3 weeks after starting sitagliptin while on long-term atorvastatin therapy. She also had low levels of 25-hydroxyvitamin D and mild chronic kidney disease, which may have contributed to the development of rhabdomyolysis. A review of the literature reveals four previous reports of this drug interaction in elderly patients, some with underlying kidney disease.

Entities:  

Keywords:  acute kidney injury; drug interaction; rhabdomyolysis; sitagliptin; statins; vitamin D

Mesh：

Substances：

Year:  2017        PMID： 28707259      PMCID： PMC5602766          DOI： 10.1007/s11606-017-4115-x

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN： 0884-8734            Impact factor:   5.128


  19 in total

1.  Vitamin D insufficiency--a novel mechanism of statin-induced myalgia?

Authors:  Paul Lee; Jerry R Greenfield; Lesley V Campbell
Journal:  Clin Endocrinol (Oxf)       Date:  2008-10-16       Impact factor: 3.478

2.  Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial.

Authors:  R Arechavaleta; T Seck; Y Chen; K J Krobot; E A O'Neill; L Duran; K D Kaufman; D Williams-Herman; B J Goldstein
Journal:  Diabetes Obes Metab       Date:  2011-02       Impact factor: 6.577

3.  Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

Authors:  Lionel Drocourt; Jean-Claude Ourlin; Jean-Marc Pascussi; Patrick Maurel; Marie-José Vilarem
Journal:  J Biol Chem       Date:  2002-05-03       Impact factor: 5.157

4.  Skeletal muscle calcium metabolism and contractile force in vitamin D-deficient chicks.

Authors:  D Pleasure; B Wyszynski; A Sumner; D Schotland; B Feldman; N Nugent; K Hitz; D B Goodman
Journal:  J Clin Invest       Date:  1979-11       Impact factor: 14.808

5.  Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use.

Authors:  D P Kao; H E Kohrt; J Kugler
Journal:  Diabet Med       Date:  2008-10       Impact factor: 4.359

Review 6.  Vitamin D and its role in skeletal muscle.

Authors:  Lisa Ceglia; Susan S Harris
Journal:  Calcif Tissue Int       Date:  2012-09-12       Impact factor: 4.333

Review 7.  Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes.

Authors:  André J Scheen
Journal:  Expert Opin Drug Metab Toxicol       Date:  2012-05-16       Impact factor: 4.481

Review 8.  Non-genomic signal transduction pathway of vitamin D in muscle.

Authors:  A R De Boland; R L Boland
Journal:  Cell Signal       Date:  1994-09       Impact factor: 4.315

9.  Pitavastatin: evidence for its place in treatment of hypercholesterolemia.

Authors:  Peter Alagona
Journal:  Core Evid       Date:  2010-10-22

10.  Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D Supplementation.

Authors:  Maksim Khayznikov; Kallish Hemachrandra; Ramesh Pandit; Ashwin Kumar; Ping Wang; Charles J Glueck
Journal:  N Am J Med Sci       Date:  2015-03
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